Document detail
ID
doi:10.1186/s13045-024-01528-7...
Author
Wang, Manni Chen, Siyuan He, Xuemei Yuan, Yong Wei, XiaweiLangue
enEditor
BioMed Central
Category
Medicine & Public Health
Year
2024
listing date
3/27/2024
Keywords
inflammation cancer therapy potential inflammatory inflammation cancerAbstract
Inflammation has accompanied human beings since the emergence of wounds and infections.
In the past decades, numerous efforts have been undertaken to explore the potential role of inflammation in cancer, from tumor development, invasion, and metastasis to the resistance of tumors to treatment.
Inflammation-targeted agents not only demonstrate the potential to suppress cancer development, but also to improve the efficacy of other therapeutic modalities.
In this review, we describe the highly dynamic and complex inflammatory tumor microenvironment, with discussion on key inflammation mediators in cancer including inflammatory cells, inflammatory cytokines, and their downstream intracellular pathways.
In addition, we especially address the role of inflammation in cancer development and highlight the action mechanisms of inflammation-targeted therapies in antitumor response.
Finally, we summarize the results from both preclinical and clinical studies up to date to illustrate the translation potential of inflammation-targeted therapies.
Wang, Manni,Chen, Siyuan,He, Xuemei,Yuan, Yong,Wei, Xiawei, 2024, Targeting inflammation as cancer therapy, BioMed Central
Projection-Specific Heterogeneity of the Axon Initial Segment of Pyramidal Neurons in the Prelimbic Cortex
heterogeneity projection-specific
