Advances and potential of regenerative medicine in pediatric nephrology

Slaats, Gisela G.; Chen, Junyu; Levtchenko, Elena; Verhaar, Marianne C.; Arcolino, Fanny Oliveira

doi:10.1007/s00467-023-06039-0

Advances and potential of regenerative medicine in pediatric nephrology

Document detail

ID

doi:10.1007/s00467-023-06039-0...

Author

Slaats, Gisela G. Chen, Junyu Levtchenko, Elena Verhaar, Marianne C. Arcolino, Fanny Oliveira

Langue

Editor

Springer

Year

2023

listing date

7/5/2023

Keywords

pediatric nephrology kidney regenerative medicine

Metrics

Abstract

The endogenous capacity of the kidney to repair is limited, and generation of new nephrons after injury for adequate function recovery remains a need.

Discovery of factors that promote the endogenous regenerative capacity of the injured kidney or generation of transplantable kidney tissue represent promising therapeutic strategies.

While several encouraging results are obtained after administration of stem or progenitor cells, stem cell secretome, or extracellular vesicles in experimental kidney injury models, very little data exist in the clinical setting to make conclusions about their efficacy.

In this review, we provide an overview of the cutting-edge knowledge on kidney regeneration, including pre-clinical methodologies used to elucidate regenerative pathways and describe the perspectives of regenerative medicine for kidney patients.

Slaats, Gisela G.,Chen, Junyu,Levtchenko, Elena,Verhaar, Marianne C.,Arcolino, Fanny Oliveira, 2023, Advances and potential of regenerative medicine in pediatric nephrology, Springer