Document detail
ID
oai:pubmedcentral.nih.gov:9532...
Topic
ReviewsAuthor
Fan, Hong‐Xia Sheng, Shuo Zhang, FengLangue
enEditor
John Wiley and Sons Inc.
Category
CNS Neuroscience & Therapeutics
Year
2022
listing date
12/12/2022
Keywords
parkinson disease pd microbiotaAbstract
There might be more than 10 million confirmed cases of Parkinson's disease (PD) worldwide by 2040.
However, the pathogenesis of PD is still unclear.
Host health is closely related to gut microbiota, which are affected by factors such as age, diet, and exercise.
Recent studies have found that gut microbiota may play key roles in the progression of a wide range of diseases, including PD.
Changes in the abundance of gut bacteria, such as Helicobacter pylori, Enterococcus faecalis, and Desulfovibrio, might be involved in PD pathogenesis or interfere with PD therapy.
Gut microbiota and the distal brain achieve action on each other through a gut‐brain axis composed of the nervous system, endocrine system, and immune system.
Here, this review focused on the current understanding of the connection between Parkinson's disease and gut microbiota, to provide potential therapeutic targets for PD.
Fan, Hong‐Xia,Sheng, Shuo,Zhang, Feng, 2022, New hope for Parkinson's disease treatment: Targeting gut microbiota, John Wiley and Sons Inc.
Projection-Specific Heterogeneity of the Axon Initial Segment of Pyramidal Neurons in the Prelimbic Cortex
heterogeneity projection-specific
