Document detail
ID
oai:HAL:hal-03951468v1
Topic
Longitudinal studies Alzheimer's Disease Brain hypometabolism Sexual dimorphism [SDV.BIBS]Life Sciences [q-bio]/Qu... [INFO.INFO-IM]Computer Science [cs...Author
Sauty, Benoît Durrleman, StanleyLangue
enEditor
HAL CCSD
Category
CNRS - Centre national de la recherche scientifique
Year
2023
listing date
12/15/2023
Keywords
disease genotype alzheimer sexAbstract
International audience; Age, sex and APOE-ε4 genotype have been identified as the strongest predictors of the risk of developing Alzheimer's Disease (AD).
This work models the pathological progression of regional brain hypometabolism, using mixed-effect models with latent time variable and longitudinal FDG-PET data.
Statistical comparisons then disentangle the effects of sex and APOE-ε4 genotype on the onset age and pace of progression of hympometabolism in each brain region, while correcting for education level.
They provide a brain map of the regions with earlier and/or faster alterations of the metabolism.
We show that females are associated with faster hypometabolism in the caudate nuclei, the thalamus and right temporal and medial-occipital lobes, while APOE-ε4 is associated with earlier hypometabolism in the limbic system (hippocampus, parahippocampus and amygdala) and temporal lobe.
Sauty, Benoît,Durrleman, Stanley, 2023, Impact of sex and APOE-ε4 genotype on regional brain metabolism in Alzheimer's Disease, HAL CCSD
