Document detail
ID
oai:pubmedcentral.nih.gov:1004...
Topic
ReviewAuthor
Zhang, Lijuan Wang, Yafei Liu, Taohui Mao, Ying Peng, BoLangue
enEditor
Springer Nature Singapore
Category
Neuroscience Bulletin
Year
2023
listing date
4/5/2023
Keywords
neurodegenerative microgliaAbstract
As prominent immune cells in the central nervous system, microglia constantly monitor the environment and provide neuronal protection, which are important functions for maintaining brain homeostasis.
In the diseased brain, microglia are crucial mediators of neuroinflammation that regulates a broad spectrum of cellular responses.
In this review, we summarize current knowledge on the multifunctional contributions of microglia to homeostasis and their involvement in neurodegeneration.
We further provide a comprehensive overview of therapeutic interventions targeting microglia in neurodegenerative diseases.
Notably, we propose microglial depletion and subsequent repopulation as promising replacement therapy.
Although microglial replacement therapy is still in its infancy, it will likely be a trend in the development of treatments for neurodegenerative diseases due to its versatility and selectivity.
Zhang, Lijuan,Wang, Yafei,Liu, Taohui,Mao, Ying,Peng, Bo, 2023, Novel Microglia-based Therapeutic Approaches to Neurodegenerative Disorders, Springer Nature Singapore
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