Document detail
ID
oai:pubmedcentral.nih.gov:1125...
Topic
ReviewAuthor
Ma, Xiangyu Guo, Jiamin Tian, Mengyao Fu, Yaoyang Jiang, Pei Zhang, Yuan Chai, RenjieLangue
enEditor
Springer Nature Singapore
Category
Neuroscience Bulletin
Year
2023
listing date
7/24/2024
Abstract
Hearing loss and deafness, as a worldwide disability disease, have been troubling human beings.
However, the auditory organ of the inner ear is highly heterogeneous and has a very limited number of cells, which are largely uncharacterized in depth.
Recently, with the development and utilization of single-cell RNA sequencing (scRNA-seq), researchers have been able to unveil the complex and sophisticated biological mechanisms of various types of cells in the auditory organ at the single-cell level and address the challenges of cellular heterogeneity that are not resolved through by conventional bulk RNA sequencing (bulk RNA-seq).
Herein, we reviewed the application of scRNA-seq technology in auditory research, with the aim of providing a reference for the development of auditory organs, the pathogenesis of hearing loss, and regenerative therapy.
Prospects about spatial transcriptomic scRNA-seq, single-cell based genome, and Live-seq technology will also be discussed.
Ma, Xiangyu,Guo, Jiamin,Tian, Mengyao,Fu, Yaoyang,Jiang, Pei,Zhang, Yuan,Chai, Renjie, 2023, Advance and Application of Single-cell Transcriptomics in Auditory Research, Springer Nature Singapore
