Document detail
ID
oai:pubmedcentral.nih.gov:1064...
Topic
Original PaperAuthor
Bożek, Andrzej Bogacz-Piaseczyńska, Agnieszka Miodońska, Martyna Sadowska, DominikaLangue
enEditor
Termedia Publishing House
Category
Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii
Year
2023
listing date
8/16/2024
Keywords
clinical rhinitis allergic patientsAbstract
INTRODUCTION: Allergen immunotherapy (AIT) is an effective therapy for allergic rhinitis and may have long-term benefits.
However, these benefits have not been strictly defined for older people.
AIM: The evaluation of the effectiveness of AIT in patients over 60 with allergic rhinitis and house dust mites (HDM) allergy over a period of 7 years was performed.
MATERIAL AND METHODS: Patients after three years of HDM-AIT were observed to assess the sustained clinical effect of treatment.
The average adjusted symptom score (AAdSS) and sIgG4 were monitored for 7 years after sublingual (SLIT) and injection AIT (SCIT).
RESULTS: After 3 years of HDM-AIT, a significant clinical effect was observed in the group after SLIT and SCIT based on AAdSS compared to the baseline and the placebo group (p < 0.05).
After 7 years of follow-up, there was a sustained trend of decrease in clinical symptoms in desensitized patients relative to placebo.
Serum sIgG4 was constantly present in all desensitized patients.
CONCLUSIONS: AIT may be beneficial for treating seniors with allergic rhinitis and allergies to house dust mites.
Bożek, Andrzej,Bogacz-Piaseczyńska, Agnieszka,Miodońska, Martyna,Sadowska, Dominika, 2023, Long-term benefit after allergen immunotherapy to HDM in elderly patients with allergic rhinitis, Termedia Publishing House
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