Document detail
ID
oai:HAL:hal-03329899v1
Topic
bilateral oophorectomy epidemiology Parkinson's disease women [SDV]Life Sciences [q-bio]Author
Canonico, Marianne Pesce, Giancarlo Bonaventure, Audrey Le Noan-Lainé, Maryline Benatru, Isabelle Ranoux, Danièle Moisan, Frédéric Elbaz, AlexisLangue
enEditor
HAL CCSD;Wiley
Category
sciences: life sciences
Year
2021
listing date
12/15/2023
Keywords
disease women 95%ci risk parkinson oophorectomy bilateral pdAbstract
International audience; Background: Results regarding the association between hormonal exposure and risk of Parkinson's disease (PD) are heterogeneous.
Objectives: To investigate the association of reproductive life characteristics with PD among postmenopausal women.
Methods: The PARTAGE case–control included 130 female cases and 255 age-matched female controls.
Information on gynecological history was obtained from a standardized questionnaire and PD was validated by neurological examination.
Odds ratios (ORs) and 95% confidence intervals (CIs) were computed using conditional logistic regression.
Results: After adjustment for education level, smoking status, professional exposure to pesticides, and coffee and alcohol drinking, bilateral oophorectomy (OR = 3.55, 95%CI = 1.75–7.20), but neither menopause before age 50 years (OR = 1.24, 95%CI = 0.74–2.09) nor hormone therapy (HT; OR = 1.07, 95%CI = 0.62–1.86), was associated with PD.
Conclusion: Our findings suggest that bilateral oophorectomy is associated with increased risk of PD.
Canonico, Marianne,Pesce, Giancarlo,Bonaventure, Audrey,Le Noan-Lainé, Maryline,Benatru, Isabelle,Ranoux, Danièle,Moisan, Frédéric,Elbaz, Alexis, 2021, Increased Risk of Parkinson's Disease in Women after Bilateral Oophorectomy, HAL CCSD;Wiley
