Document detail
ID
oai:HAL:hal-03977652v1
Topic
Coral reef Clownfish Metamorphosis Thyroid hormones Transcriptomic Vision Metabolism [SDV]Life Sciences [q-bio]Author
Roux, Natacha Miura, Saori Dussene, Mélanie Tara, Yuki Lee, Fiona de Bernard, Simon Reynaud, Mathieu Salis, Pauline Barua, Agneesh Boulahtouf, Abdelhay Balaguer, Patrick Gauthier, Karine Lecchini, David Gibert, Yann Besseau, Laurence Laudet, VincentLangue
enEditor
HAL CCSD;Elsevier Inc
Category
sciences: life sciences
Year
2023
listing date
12/15/2023
Keywords
thyroid hormonesAbstract
International audience; Most marine organisms have a biphasic life cycle during which a pelagic larva is transformed into a radically different juvenile.
In vertebrates the role of thyroid hormones (TH) in triggering this transition is well known, but how the morphological and physiological changes are integrated in a coherent way with the ecological transition remains poorly explored.
To gain insight into this question, we performed an integrative analysis of metamorphosis of a marine teleost, the clownfish Amphiprion ocellaris.
We reveal how TH coordinate a change in color vision as well as a major metabolic shift in energy production, hence highlighting its central integrative role in regulating this transformation.
By manipulating the activity of LXR, a major regulator of metabolism, we also reveal a tight link between metabolic changes and metamorphosis progression.
Strikingly, we observed that these regulations are at play in the wild revealing how hormones coordinate energy needs with available resources during life cycle.
Roux, Natacha,Miura, Saori,Dussene, Mélanie,Tara, Yuki,Lee, Fiona,de Bernard, Simon,Reynaud, Mathieu,Salis, Pauline,Barua, Agneesh,Boulahtouf, Abdelhay,Balaguer, Patrick,Gauthier, Karine,Lecchini, David,Gibert, Yann,Besseau, Laurence,Laudet, Vincent, 2023, The multi-level regulation of clownfish metamorphosis by thyroid hormones, HAL CCSD;Elsevier Inc
