Document detail
ID
oai:pubmedcentral.nih.gov:1060...
Topic
Original ArticleAuthor
Song, Siyuan Yuan, Yumin Xu, Lingling Jiang, Jun Li, Ying Yan, Yao Li, Qing Zhou, Fang Cao, Junli Zhang, LicaiLangue
enEditor
Springer Nature Singapore
Category
Neuroscience Bulletin
Year
2023
listing date
11/1/2023
Keywords
associated nucleusAbstract
We previously identified a unique nucleus, the cerebrospinal fluid (CSF)-contacting nucleus.
This study aims to understand its gene architecture and preliminarily suggest its functions.
The results showed that there were about 19,666 genes in this nucleus, of which 913 were distinct from the dorsal raphe nucleus (non-CSF contacting).
The top 40 highly-expressed genes are mainly related to energy metabolism, protein synthesis, transport, secretion, and hydrolysis.
The main neurotransmitter is 5-HT.
The receptors of 5-HT and GABA are abundant.
The channels for Cl(–), Na(+), K(+), and Ca(2+) are routinely expressed.
The signaling molecules associated with the CaMK, JAK, and MAPK pathways were identified accurately.
In particular, the channels of transient receptor potential associated with nociceptors and the solute carrier superfamily members associated with cell membrane transport were significantly expressed.
The relationship between the main genes of the nucleus and life activities is preliminarily verified.
Song, Siyuan,Yuan, Yumin,Xu, Lingling,Jiang, Jun,Li, Ying,Yan, Yao,Li, Qing,Zhou, Fang,Cao, Junli,Zhang, Licai, 2023, Genetic Architecture and Functional Implications of the CSF-Contacting Nucleus, Springer Nature Singapore
