Documentdetail
ID kaart
doi:10.1007/s13577-023-00895-6...
Auteur
Mito, Remi Iriki, Toyohisa Fujiwara, Yukio Pan, Cheng Ikeda, Tsuyoshi Nohara, Toshihiro Suzuki, Makoto Sakagami, Takuro Komohara, YoshihiroLangue
enEditor
Springer
Categorie
Life Sciences
Jaar
2023
vermelding datum
29-03-2023
Trefwoorden
small-cell lung cancer interleukin-6 signal transducer and activator of... tumor-associated macrophage cell–cell interaction cancer il-6 proliferation compounds natural sclc cell–cell onaBeschrijving
Tumor-associated macrophage (TAM)-derived IL-6 is involved in small-cell lung cancer (SCLC) progression and chemoresistance via the activation of signal transducer and activator of transcription 3 (STAT3) in the tumor microenvironment.
This study aimed to identify natural compounds that suppress cell–cell interactions between TAMs and SCLC cells by inhibiting STAT3 activation.
We used a library of natural compounds to identify candidate agents possessing anti-SCLC effects by inhibiting macrophage-induced tumor proliferation.
SBC-3 and SBC-5, human SCLC cell lines, were used for in vitro experiments.
Furthermore, we assessed the efficacy of these candidate agents in a murine xenograft model of human SCLC.
Among the natural compounds examined, onionin A (ONA) inhibited IL-6-induced STAT3 activation and SCLC cell proliferation.
ONA also reduced the secretion of IL-6 from macrophages and interfered with the direct effect of cell–cell interactions between macrophages and SCLC cells.
Furthermore, ONA administration suppressed tumor progression in a tumor-bearing mouse model.
ONA was identified as the most useful candidate for targeting cell–cell interactions between cancer cells and TAMs for anti-SCLC therapy.
Mito, Remi,Iriki, Toyohisa,Fujiwara, Yukio,Pan, Cheng,Ikeda, Tsuyoshi,Nohara, Toshihiro,Suzuki, Makoto,Sakagami, Takuro,Komohara, Yoshihiro, 2023, Onionin A inhibits small-cell lung cancer proliferation through suppressing STAT3 activation induced by macrophages-derived IL-6 and cell–cell interaction with tumor-associated macrophage, Springer
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