Documentdetail
ID kaart
doi:10.1007/s11864-024-01238-9...
Auteur
Kuang, Ziyu Ge, Yuansha Cao, Luchang Wang, Xinmiao Liu, Kexin Wang, Jiaxi Zhu, Xiaojuan Wu, Min Li, JieLangue
enEditor
Springer
Categorie
Medicine & Public Health
Jaar
2024
vermelding datum
31-07-2024
Trefwoorden
anthracycline cardiotoxicity cancer chemotherapy doxorubicin heart failure aicBeschrijving
Anthracycline (ANT)-induced cardiotoxicity (AIC) is a particularly prominent form of cancer therapy-related cardiovascular toxicity leading to the limitations of ANTs in clinical practice.
Even though AIC has drawn particular attention, the best way to treat it is remaining unclear.
Updates to AIC therapy have been made possible by recent developments in research on the underlying processes of AIC.
We review the current molecular pathways leading to AIC: 1) oxidative stress (OS) including enzymatic-induced and other mechanisms; 2) topoisomerase; 3) inflammatory response; 4) cardiac progenitor cell damage; 5) epigenetic changes; 6) renin-angiotensin-aldosterone system (RAAS) dysregulation.
And we systematically discuss current prevention and treatment strategies and novel pathogenesis-based therapies for AIC: 1) dose reduction and change; 2) altering drug delivery methods; 3) antioxidants, dexrezosen, statina, RAAS inhibitors, and hypoglycemic drugs; 4) miRNA, natural phytochemicals, mesenchymal stem cells, and cardiac progenitor cells.
We also offer a fresh perspective on the management of AIC by outlining the current dilemmas and challenges associated with its prevention and treatment.
Kuang, Ziyu,Ge, Yuansha,Cao, Luchang,Wang, Xinmiao,Liu, Kexin,Wang, Jiaxi,Zhu, Xiaojuan,Wu, Min,Li, Jie, 2024, Precision Treatment of Anthracycline-Induced Cardiotoxicity: An Updated Review, Springer
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