Documentdetail
ID kaart
doi:10.1007/s12609-023-00516-z...
Auteur
Natsuhara, Kelsey H. Chien, A. JoLangue
enEditor
Springer
Categorie
Medicine & Public Health
Jaar
2024
vermelding datum
10-01-2024
Trefwoorden
breast cancer fertility fertility preservation reproductive health ovarian breast cancer systemic women therapy fertilityBeschrijving
Purpose of Review Fertility concerns are common among young women diagnosed with breast cancer, as systemic therapy increases the risk of premature ovarian insufficiency and delays family planning.
Here, we review the impact of systemic therapies, including chemotherapy, endocrine therapy, HER-2 directed therapy, PARP inhibitors, and immunotherapy, on ovarian reserve.
Recent Findings With an improved understanding of disease biology, fewer women are treated with gonadotoxic chemotherapy.
There are limited data on the fertility impact of novel targeted treatments and immunotherapy, though preclinical and preliminary studies suggest an impact on fertility is possible.
Notably, a recent study investigated the outcomes in women who interrupted adjuvant endocrine therapy to attempt pregnancy.
Summary Further research is needed to characterize the fertility impact of novel therapies in breast cancer.
Individualized fertility counseling should be offered to all women to discuss the possible impact of therapy on ovarian reserve and options for fertility preservation and timing of pregnancy.
Natsuhara, Kelsey H.,Chien, A. Jo, 2024, Impact of Systemic Therapy on Fertility in Women with Early-Stage Breast Cancer, Springer
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