Documentdetail
ID kaart

doi:10.1007/s40121-024-00959-6...

Auteur
Quercia, Romina Perri, Giovanni Pein, Carolina Bodie, Jennifer Singh, Ravi Shankar P. Hendrick, Victoria Boffito, Marta
Langue
en
Editor

Springer

Categorie

Medicine & Public Health

Jaar

2024

vermelding datum

17-04-2024

Trefwoorden
concomitant medication management covid-19 drug–drug interactions hiv nirmatrelvir ritonavir pk
Metriek

Beschrijving

Ritonavir is a potent inhibitor of the cytochrome P450 3A4 enzyme and is commonly used as a pharmacokinetic (PK) enhancer in antiviral therapies because it increases bioavailability of concomitantly administered antivirals.

Decades of experience with ritonavir-enhanced HIV therapies and, more recently, COVID-19 therapies demonstrate that boosting doses of ritonavir are well tolerated, with an established safety profile.

The mechanisms of PK enhancement by ritonavir result in the potential for drug–drug interactions (DDIs) with several classes of drugs, thus making co-medication management an important consideration with enhanced antiviral therapies.

However, rates of DDIs with contraindicated medications are low, suggesting these risks are manageable by infectious disease specialists who have experience with the use of PK enhancers.

In this review, we provide an overview of ritonavir’s mechanisms of action and describe approaches and resources available to mitigate adverse events and manage concomitant medication in both chronic and short-term settings.

Quercia, Romina,Perri, Giovanni,Pein, Carolina,Bodie, Jennifer,Singh, Ravi Shankar P.,Hendrick, Victoria,Boffito, Marta, 2024, Ritonavir: 25 Years’ Experience of Concomitant Medication Management. A Narrative Review, Springer

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