Documentdetail
ID kaart

doi:10.1186/s12879-023-08706-x...

Auteur
Xu, Fan Gan, Xiuyuan Tao, Yang Li, Dongling Xie, Puguang Liu, Fangying Yang, Fan Ma, Yu
Langue
en
Editor

BioMed Central

Categorie

Medicine & Public Health

Jaar

2023

vermelding datum

18-10-2023

Trefwoorden
two-sample mendelian randomization... influenza pneumonia gwas connection causal bacterial infection egger association gut microbiota pneumonia ivw influenza bidirectional
Metriek

Beschrijving

Background Previous observational studies have indicated a correlation between the gut microbiota and influenza; however, the exact nature of the bidirectional causal connection remains uncertain.

Method A two-way, two-sample Mendelian randomization (MR) study was conducted to evaluate the possible causal connection between the gut microbiota and the two outcomes of influenza (pneumonia without influenza and influenza pneumonia).

The statistical analysis of gut microbiota is derived from the information of the most extensive meta-analysis (GWAS) conducted by the MiBioGen Alliance, encompassing a sample size of 18,340.

The summary statistical data for influenza (not pneumonia, n = 291,090) and influenza pneumonia (n = 342,499) are from GWAS data published by FinnGen consortium R8.Estimate and summarize Single-nucleotide polymorphisms (SNPs) using Inverse variance weighted (IVW), MR Egger, and Weighted median (WM) in bidirectional MR analysis.

To assess the heterogeneity, horizontal pleiotropy, and stability of SNPs, we employed Cochran’s Q test, MR Egger intercept test, and sensitivity analysis.

Result The IVW analysis indicated that there was a significant association between influenza infection and five bacterial taxa.

Additionally, the abundance changes of seven gut microbiota were found to be causally related to influenza infection.

In addition, seven bacterial taxa showed a significant association with the occurrence of influenza pneumonia.

The findings from the WM analysis largely support the outcomes of IVW, however, the results of MR egger analysis do not align with IVW.

Furthermore, there is no proof to substantiate the cause-and-effect relationship between influenza pneumonia and the composition of gut microbiota.

Conclusion This analysis demonstrates a possible bidirectional causal connection between the prevalence of particular gut microbiota and the occurrence of influenza infection.

The presence of certain gut microbiota may potentially contribute to the development of pneumonia caused by influenza.

Additional investigation into the interaction between particular bacterial communities and influenza can enhance efforts in preventing, monitoring, and treating influenza.

Xu, Fan,Gan, Xiuyuan,Tao, Yang,Li, Dongling,Xie, Puguang,Liu, Fangying,Yang, Fan,Ma, Yu, 2023, Association between gut microbiota and influenza: a bidirectional two-sample mendelian randomization study, BioMed Central

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