Documentdetail
ID kaart
doi:10.1007/s00467-024-06397-3...
Auteur
Brüning, Klara Kristin Pelivan, Elena Heinrich, Marie-Christine Bufler, Philip Kaindl, Angela Thumfart, JuliaLangue
enEditor
Springer
Categorie
Urology
Jaar
2024
vermelding datum
29-05-2024
Trefwoorden
dress (drug reaction with eosinoph... lamotrigine acute interstitial nephritis (ain)... non-adherence syndrome dress lamotrigine injuryBeschrijving
We present a case of lamotrigine-triggered DRESS (drug reaction with eosinophilia and systemic symptoms) syndrome with acute kidney injury stage 3.
A 17-year-old girl with known epilepsy treated with lamotrigine presented with acute kidney injury as well as skin eruption, fever, and apathy.
Extended diagnostics, considering infectious and autoimmune diseases, remained unremarkable.
Lamotrigine blood levels were within the target range.
Kidney biopsy showed acute interstitial nephritis with tubular necrosis.
Methylprednisolone pulse therapy led to an improvement in kidney function; skin eruption and neurological symptoms resolved.
During the hospital stay, the girl admitted to inconsistent and variable intake of lamotrigine, occasionally resulting in notable overdosing.
This report demonstrates that acute kidney injury in lamotrigine-induced DRESS syndrome is an acute interstitial nephritis with tubular necrosis, an aspect that has not been deeply characterized so far.
Additionally, we aim to elevate awareness towards non-adherence as cause of disease, especially among the adolescent population.
Brüning, Klara Kristin,Pelivan, Elena,Heinrich, Marie-Christine,Bufler, Philip,Kaindl, Angela,Thumfart, Julia, 2024, Acute kidney injury in lamotrigine-induced DRESS syndrome, Springer
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