Documentdetail
ID kaart
oai:HAL:hal-03213105v1
Onderwerp
Africa Influenza virus antigenic cartography one health phylogeny [SDV]Life Sciences [q-bio]Auteur
Fusade-Boyer, Maxime Djegui, Fidélia Batawui, Komla Byuragaba, Denis, K. Jones, Jeremy, C. Wabwire-Mangeni, Fred Erima, Bernard Atim, Gladys Ukuli, Qouilazoni, A. Tugume, Titus Dogno, Koffi Adjabli, Komlan Nzuzi, Mvibudulu Adjin, Rachidatou Jeevan, Trushar Rubrum, Adam Go-Maro, Wolali Kayali, Ghazi Mckenzie, Pamela Webby, Richard, J. Ducatez, MarietteLangue
enEditor
HAL CCSD;Earliest : Springer-Nature ; Latest : Taylor & Francis
Categorie
wetenschappen: levenswetenschappen
Jaar
2021
vermelding datum
08-12-2023
Trefwoorden
sub-saharan h9n2 pathogenic uganda togo benin antigenic viruses influenzaBeschrijving
International audience; Sub-Saharan Africa was historically considered an animal influenza cold spot, with only sporadic highly pathogenic H5 outbreaks detected over the last 20 years.
However, in 2017, low pathogenic avian influenza A(H9N2) viruses were detected in poultry in Sub-Saharan Africa.
Molecular, phylogenetic, and antigenic characterization of isolates from Benin, Togo, and Uganda showed that they belonged to the G1 lineage.
Isolates from Benin and Togo clustered with viruses previously described in Western Africa, whereas viruses from Uganda were genetically distant and clustered with viruses from the Middle East.
Viruses from Benin exhibited decreased cross-reactivity with those from Togo and Uganda, suggesting antigenic drift associated with reduced replication in Calu-3 cells.
The viruses exhibited mammalian adaptation markers similar to those of the human strain A/Senegal/0243/2019 (H9N2).
Therefore, viral genetic and antigenic surveillance in Africa is of paramount importance to detect further evolution or emergence of new zoonotic strains.
Fusade-Boyer, Maxime,Djegui, Fidélia,Batawui, Komla,Byuragaba, Denis, K.,Jones, Jeremy, C.,Wabwire-Mangeni, Fred,Erima, Bernard,Atim, Gladys,Ukuli, Qouilazoni, A.,Tugume, Titus,Dogno, Koffi,Adjabli, Komlan,Nzuzi, Mvibudulu,Adjin, Rachidatou,Jeevan, Trushar,Rubrum, Adam,Go-Maro, Wolali,Kayali, Ghazi,Mckenzie, Pamela,Webby, Richard, J.,Ducatez, Mariette, 2021, Antigenic and molecular characterization of low pathogenic avian influenza A(H9N2) viruses in sub-Saharan Africa from 2017 through 2019, HAL CCSD;Earliest : Springer-Nature ; Latest : Taylor & Francis
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