Document detail
ID
oai:pubmedcentral.nih.gov:9213...
Topic
Precision Vaccines SupplementAuthor
Lofgren, Eric Naumova, Elena N. Gorski, Jack Naumov, Yuri Fefferman, Nina H.Langue
enEditor
Oxford University Press
Category
Oxford University Press Public Health Emergency Collection
Year
2022
listing date
1/13/2023
Keywords
respiratory theories challenges influenza infections vaccinesAbstract
Vaccines against seasonal infections like influenza offer a recurring testbed, encompassing challenges in design, implementation, and uptake to combat a both familiar and ever-shifting threat.
One of the pervading mysteries of influenza epidemiology is what causes the distinctive seasonal outbreak pattern.
Proposed theories each suggesting different paths forwards in being able to tailor precision vaccines and/or deploy them most effectively.
One of the greatest challenges in contrasting and supporting these theories is, of course, that there is no means by which to actually test them.
In this communication we revisit theories and explore how the ongoing COVID-19 pandemic might provide a unique opportunity to better understand the global circulation of respiratory infections.
We discuss how vaccine strategies may be targeted and improved by both isolating drivers and understanding the immunological consequences of seasonality, and how these insights about influenza vaccines may generalize to vaccines for other seasonal respiratory infections.
Lofgren, Eric,Naumova, Elena N.,Gorski, Jack,Naumov, Yuri,Fefferman, Nina H., 2022, How drivers of seasonality in respiratory infections may impact vaccine strategy: a case study in how COVID-19 may help us solve one of influenza's biggest challenges, Oxford University Press
