Document detail
ID

doi:10.1007/s12029-024-01059-x...

Author
Li, Ju Wang, Wanqing Jiang, Kaipeng Cui, Jiuwei Wang, Chang Liang, Tingting Wang, Yizhuo Liu, Shuhan Zhou, Wenshuo
Langue
en
Editor

Springer

Category

Medicine & Public Health

Year

2024

listing date

5/8/2024

Keywords
cancer thrombocytopenia chemotherapy risk factors baseline nk dose total albumin multivariate cell stage patients gastrointestinal oxaliplatin analysis metastasis thrombocytopenia
Metrics

Abstract

Purpose Thrombocytopenia is among the most common chemotherapy-related hematologic toxicities.

We aim to determine the predictors of oxaliplatin chemotherapy-induced thrombocytopenia in patients with gastrointestinal tumors to guide the clinic.

Methods Clinical data of 750 patients with a malignant gastrointestinal tumor were included as the primary cohort.

Basic clinical data, serological indices, and anthropometric indices of these patients were collected.

According to the presence or absence of CIT, univariate analysis was performed to identify significant factors for multivariate analysis.

In R language software, nomogram was constructed based on the results of multi-factor analysis, and the calibration curve and ROC curve were drawn.

Results Univariate analysis identified 17 factors as closely related to CIT occurrence, namely age, lymph node metastasis (N) stage, metastasis (M) stage, lung metastasis, other site metastasis, chemotherapy regimen, course of treatment, total dose of oxaliplatin, AST, albumin, neutrophils, monocytes, baseline platelets, transferrin, natural killer (NK) cell, phase angle, and SMI ( P  < 0.10).

The binary logistic multivariate regression analysis revealed five independent risk factors for developing CIT ( P  < 0.05), including the M stage, total dose of oxaliplatin, albumin, baseline thrombocyte count, and NK cell.

Based on the results of multivariate logistic regression analysis, R software was used to establish a nomogram model.

The calibration curve shows that the combined predictor has good consistency.

The area under the ROC curve was 0.877 and the best cut-off value was 0.3579613 (sensitivity, 78.9%; specificity, 81.8%), which showed the better prediction efficiency.

Conclusion The total dose of oxaliplatin, M stage, albumin, baseline platelet count, and NK cell was independent risk factors for CIT.

The sequentially constructed histogram model had a good predictive effect on the risk of thrombocytopenia caused by oxaliplatin chemotherapy in patients with gastrointestinal malignancies.

Li, Ju,Wang, Wanqing,Jiang, Kaipeng,Cui, Jiuwei,Wang, Chang,Liang, Tingting,Wang, Yizhuo,Liu, Shuhan,Zhou, Wenshuo, 2024, Risk Factors of Chemotherapy-Induced Thrombocytopenia After Oxaliplatin-Containing Chemotherapy for Gastrointestinal Malignancies, Springer

Document

Open

Share

Source

Articles recommended by ES/IODE AI

A Novel MR Imaging Sequence of 3D-ZOOMit Real Inversion-Recovery Imaging Improves Endolymphatic Hydrops Detection in Patients with Ménière Disease
ménière disease p < detection imaging sequences 3d-zoomit 3d endolymphatic real tse reconstruction ir inversion-recovery hydrops ratio
Successful omental flap coverage repair of a rectovaginal fistula after low anterior resection: a case report
rectovaginal fistula rectal cancer low anterior resection omental flap muscle flap rectal cancer pod initial repair rvf flap omental lar coverage