Dokumentdetails
ID
doi:10.1007/s10654-023-00965-x...
Autor
Beukenhorst, Anna L. Koch, Clarissa M. Hadjichrysanthou, Christoforos Alter, Galit Wolf, Frank Anderson, Roy M. Goudsmit, JaapLangue
enEditor
Springer
Kategorie
Epidemiology
Jahr
2023
Auflistungsdatum
08.02.2023
Schlüsselwörter
respiratory infections sars-cov-2 pandemic covid-19 influenza vaccines vaccine effectiveness infection coronavirus immunology control measures herd immunity population modelling severe sars-cov-2 covid-19 strategies immunity vaccinationZusammenfassung
Neither vaccination nor natural infection result in long-lasting protection against SARS-COV-2 infection and transmission, but both reduce the risk of severe COVID-19.
To generate insights into optimal vaccination strategies for prevention of severe COVID-19 in the population, we extended a Susceptible-Exposed-Infectious-Removed (SEIR) mathematical model to compare the impact of vaccines that are highly protective against severe COVID-19 but not against infection and transmission, with those that block SARS-CoV-2 infection.
Our analysis shows that vaccination strategies focusing on the prevention of severe COVID-19 are more effective than those focusing on creating of herd immunity.
Key uncertainties that would affect the choice of vaccination strategies are: (1) the duration of protection against severe disease, (2) the protection against severe disease from variants that escape vaccine-induced immunity, (3) the incidence of long-COVID and level of protection provided by the vaccine, and (4) the rate of serious adverse events following vaccination, stratified by demographic variables.
Beukenhorst, Anna L.,Koch, Clarissa M.,Hadjichrysanthou, Christoforos,Alter, Galit,Wolf, Frank,Anderson, Roy M.,Goudsmit, Jaap, 2023, SARS-CoV-2 elicits non-sterilizing immunity and evades vaccine-induced immunity: implications for future vaccination strategies, Springer
