Highly pathogenic avian influenza A(H5N1) virus in a common bottlenose dolphin (Tursiops truncatus) in Florida

Murawski, Allison; Fabrizio, Thomas; Ossiboff, Robert; Kackos, Christina; Jeevan, Trushar; Jones, Jeremy C.; Kandeil, Ahmed; Walker, David; Turner, Jasmine C. M.; Patton, Christopher; Govorkova, Elena A.; Hauck, Helena; Mickey, Suzanna; Barbeau, Brittany; Bommineni, Y. Reddy; Torchetti, Mia; Lantz, Kristina; Kercher, Lisa; Allison, Andrew B.; Vogel, Peter; Walsh, Michael; Webby, Richard J.

doi:10.1038/s42003-024-06173-x

Highly pathogenic avian influenza A(H5N1) virus in a common bottlenose dolphin (Tursiops truncatus) in Florida

Dokumentdetails

ID

doi:10.1038/s42003-024-06173-x...

Autor

Murawski, Allison Fabrizio, Thomas Ossiboff, Robert Kackos, Christina Jeevan, Trushar Jones, Jeremy C. Kandeil, Ahmed Walker, David Turner, Jasmine C. M. Patton, Christopher Govorkova, Elena A. Hauck, Helena Mickey, Suzanna Barbeau, Brittany Bommineni, Y. Reddy Torchetti, Mia Lantz, Kristina Kercher, Lisa Allison, Andrew B. Vogel, Peter Walsh, Michael Webby, Richard J.

Langue

Editor

Nature

Kategorie

Life Sciences

Jahr

2024

Auflistungsdatum

24.04.2024

Schlüsselwörter

influenza hpai united highly pathogenic h5n1 avian

Metrisch

Zusammenfassung

A case report of highly pathogenic avian influenza A H5N1 of clade 2.3.4.4b in the brain of a common bottlenose dolphin (Tursiops truncatus) from Florida, United States.

Since late 2021, highly pathogenic avian influenza (HPAI) viruses of A/goose/Guangdong/1/1996 (H5N1) lineage have caused widespread mortality in wild birds and poultry in the United States.

Concomitant with the spread of HPAI viruses in birds are increasing numbers of mammalian infections, including wild and captive mesocarnivores and carnivores with central nervous system involvement.

Here we report HPAI, A(H5N1) of clade 2.3.4.4b, in a common bottlenose dolphin ( Tursiops truncatus ) from Florida, United States.

Pathological findings include neuronal necrosis and inflammation of the brain and meninges, and quantitative real time RT-PCR reveal the brain carried the highest viral load.

Virus isolated from the brain contains a S246N neuraminidase substitution which leads to reduced inhibition by neuraminidase inhibitor oseltamivir.

The increased prevalence of A(H5N1) viruses in atypical avian hosts and its cross-species transmission into mammalian species highlights the public health importance of continued disease surveillance and biosecurity protocols.

Murawski, Allison,Fabrizio, Thomas,Ossiboff, Robert,Kackos, Christina,Jeevan, Trushar,Jones, Jeremy C.,Kandeil, Ahmed,Walker, David,Turner, Jasmine C. M.,Patton, Christopher,Govorkova, Elena A.,Hauck, Helena,Mickey, Suzanna,Barbeau, Brittany,Bommineni, Y. Reddy,Torchetti, Mia,Lantz, Kristina,Kercher, Lisa,Allison, Andrew B.,Vogel, Peter,Walsh, Michael,Webby, Richard J., 2024, Highly pathogenic avian influenza A(H5N1) virus in a common bottlenose dolphin (Tursiops truncatus) in Florida, Nature