Dokumentdetails
ID
doi:10.1007/s12020-023-03554-w...
Autor
Xu, Fa-Zhan Zheng, Lu-Lu Chen, Ke-Hao Wang, Ru Yi, Dan-Dan Jiang, Chao-Yu Liu, Zhi-Jian SHI, Xian-Biao Sang, Jian-FengLangue
enEditor
Springer
Kategorie
Medicine & Public Health
Jahr
2023
Auflistungsdatum
11.10.2023
Schlüsselwörter
papillary thyroid cancer sex hormone testosterone estradiol male correlated hormone tumor ptc pathological thyroid features patientsZusammenfassung
Purpose Sex hormones are thought to be responsible for the unique gender differences in papillary thyroid cancer(PTC).
Most previous studies on these have focused on the expression of estrogen receptors, or have been limited to animal studies.
The aim of our study was to explore the relationship between serum sex hormones and the pathological features of PTC in the clinical setting, as further evidence of the role of sex hormones in PTC.
Methods Retrospective data analysis of patients who underwent thyroid surgery at the Department of Thyroid Surgery, Nanjing Drum Tower Hospital from January 2022 to September 2022 Correlation between serum sex hormone and pathological features was analyzed in male patients and in menopausal female patients.
Serum sex hormones include luteinizing hormone(LH), follicle stimulating hormone(FSH), estradiol(E_2), total testosterone(TT), progesterone(P), and prolactin(PRL).
Tumor pathological characteristics include the number and size of tumor, presence of extrathyroidal extension(ETE), presence of lymph node metastasis(LNM).
Results Preoperative serum E2 in male patients was positively correlated with tumor size in PTC, LH was negatively correlated with LNM, while TT and P were negatively correlated with ETE.
Similar findings were not observed in menopausal female patients.
Conclusion We observed that serum sex hormones correlate with the pathological features of PTC in male patients, for the first time in a clinical study.
High serum estrogens may be a risk factor for PTC, while androgens are the opposite.
This somewhat corroborates previous research and provides new variables for future PTC prediction models.
Xu, Fa-Zhan,Zheng, Lu-Lu,Chen, Ke-Hao,Wang, Ru,Yi, Dan-Dan,Jiang, Chao-Yu,Liu, Zhi-Jian,SHI, Xian-Biao,Sang, Jian-Feng, 2023, Serum sex hormones correlate with pathological features of papillary thyroid cancer, Springer
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