Dokumentdetails
ID
doi:10.1038/s41433-022-02207-y...
Autor
Fieß, Achim Greven, Katrin Mildenberger, Eva Urschitz, Michael S. Elflein, Heike M. Zepp, Fred Stoffelns, Bernhard Pfeiffer, Norbert Schuster, Alexander K.Langue
enEditor
Nature
Kategorie
Medicine & Public Health
Jahr
2022
Auflistungsdatum
21.09.2022
Schlüsselwörter
dcva prematurity treated ga rop visual preterm weeks study acuity amblyopiaZusammenfassung
Objectives This study investigated the effects of prematurity and ROP on visual acuity and VRQoL in adults (18–52 years).
Methods The Gutenberg Prematurity Eye Study is a retrospective cohort study with a prospective ophthalmologic examination.
Preterm and full-term participants at an age from 18 to 52 years were included.
Distant corrected visual acuity (DCVA) and VRQoL were assessed in participants (892 eyes of 450 individuals aged 28.6 ± 8.6 years, 251 females) grouped into full-term controls (gestational age [GA] at birth ≥37 weeks), preterm participants without ROP and GA 33–36 weeks (group 2), GA 29–32 weeks (group 3), GA ≤ 28 weeks (group 4), non-treated ROP (group 5) and treated ROP (group 6).
Main outcome measures were distant corrected visual acuity (DCVA), VRQoL and prevalence of amblyopia.
Results The DCVA of the better eye correlated ( p < 0.001) with GA, birth weight, ROP, ROP treatment, and perinatal adverse events and was poorer in both ROP groups.
Visual acuity of <20/200 in the better eye was observed in two participants (4.2%) in the ROP group and one person (6.7%) in the treated ROP group.
The prevalence of amblyopia increased in the ROP groups.
Compared to full-term controls, visual functioning VRQoL scores were lower in preterm individuals independent of ROP while socioemotional VRQoL scores were only lower in the treated ROP group.
Conclusion Participants with postnatal ROP and its treatment showed decreased visual acuity and VRQol in adulthood, with amblyopia occurring more frequently in more preterm participants with ROP.
Fieß, Achim,Greven, Katrin,Mildenberger, Eva,Urschitz, Michael S.,Elflein, Heike M.,Zepp, Fred,Stoffelns, Bernhard,Pfeiffer, Norbert,Schuster, Alexander K., 2022, Visual acuity, amblyopia, and vision-related quality of life in preterm adults with and without ROP: results from the Gutenberg prematurity eye study, Nature
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