Dokumentdetails
ID
doi:10.1186/s13048-024-01451-y...
Autor
Wang, Ru Lv, Youyuan Dou, Tao Yang, Qian Yu, Chunxiao Guan, QingboLangue
enEditor
BioMed Central
Kategorie
Medicine & Public Health
Jahr
2024
Auflistungsdatum
19.06.2024
Schlüsselwörter
autoimmune thyroid disease hyperthyroidism hypothyroidism ovarian premature ovarian failure disease thyroid autoimmuneZusammenfassung
Thyroid hormones(THs) are essential for the proper functioning of the ovaries, and multiple studies have shown that thyroid abnormalities, especially during adolescence and reproductive age, can lead to lifelong ovarian dysfunction.
Autoimmune thyroid disease (AITD), one of the most common organ specific autoimmune diseases, is mainly mediated by cellular autoimmune reactions, and has strong inflammatory infiltration and immune active cells, including chemokines and cytokines, which are important components of ovarian aging.
This suggests that autoimmune and inflammatory molecular processes may play a role in the emergence of ovarian dysfunction.
The purpose of this review is to summarize recent in vivo and in vitro evidence of a complex relationship between AITD and ovarian dysfunction.
AITD is closely related to the decline of ovarian function from the perspective of antibody, cytokine, oxidative stress, and genetic factors.
Finally, some of the currently known treatments for AITD and hypo ovarian disease are summarized.
Wang, Ru,Lv, Youyuan,Dou, Tao,Yang, Qian,Yu, Chunxiao,Guan, Qingbo, 2024, Autoimmune thyroid disease and ovarian hypofunction: a review of literature, BioMed Central
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