Dokumentdetails
ID

doi:10.1186/s12866-023-02970-2...

Autor
Araújo, Vítor Fehn, Anne-Maria Phiri, Admire Wills, Jeffrey Rocha, Jorge Gayà-Vidal, Magdalena
Langue
en
Editor

BioMed Central

Kategorie

Mycology

Jahr

2023

Auflistungsdatum

23.08.2023

Schlüsselwörter
oral microbiota oral microbiome saliva exome sequencing metagenomics socio-economic status subsistence methods african populations
Metrisch

Zusammenfassung

Background While the human oral microbiome is known to play an important role in systemic health, its average composition and diversity patterns are still poorly understood.

To gain better insights into the general composition of the microbiome on a global scale, the characterization of microbiomes from a broad range of populations, including non-industrialized societies, is needed.

Here, we used the portion of non-human reads obtained through an expanded exome capture sequencing approach to characterize the saliva microbiomes of 52 individuals from eight ethnolinguistically diverse southern African populations from Angola (Kuvale, Kwepe, Himba, Tjimba, Kwisi, Twa, !

Xun) and Zimbabwe (Tshwa), including foragers, food-producers, and peripatetic groups (low-status communities who provide services to their dominant neighbors).

Results Our results indicate that neither host genetics nor livelihood seem to influence the oral microbiome profile, with Neisseria , Streptococcus , Prevotella , Rothia , and Porphyromonas being the five most frequent genera in southern African groups, in line with what has been shown for other human populations.

However, we found that some Tshwa and Twa individuals display an enrichment of pathogenic genera from the Enterobacteriaceae family (i.e. Enterobacter , Citrobacter , Salmonella ) of the Proteobacteria phylum, probably reflecting deficient sanitation and poor health conditions associated with social marginalization.

Conclusions Taken together, our results suggest that socio-economic status, rather than ethnolinguistic affiliation or subsistence mode, is a key factor in shaping the salivary microbial profiles of human populations in southern Africa.

Araújo, Vítor,Fehn, Anne-Maria,Phiri, Admire,Wills, Jeffrey,Rocha, Jorge,Gayà-Vidal, Magdalena, 2023, Oral microbiome homogeneity across diverse human groups from southern Africa: first results from southwestern Angola and Zimbabwe, BioMed Central

Dokumentieren

Öffnen

Teilen

Quelle

Artikel empfohlen von ES/IODE AI

Systematic druggable genome-wide Mendelian randomization identifies therapeutic targets for lung cancer
agphd1 subtypes replication hykk squamous cell gene carcinoma causal targets mendelian randomization cancer analysis