Dokumentdetails
ID
oai:pubmedcentral.nih.gov:1022...
Thema
ResearchAutor
Stirton, Hannah Kosowan, Leanne Abrams, Elissa M Protudjer, Jennifer LP Queenan, John Singer, AlexanderLangue
enEditor
BioMed Central
Kategorie
Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology
Jahr
2023
Auflistungsdatum
22.09.2023
Schlüsselwörter
8% medical using eczema care ppv se sp primary definitionZusammenfassung
BACKGROUND: To validate case definitions for eczema using primary care Electronic Medical Record (EMR) data from the Canadian Primary Care Sentential Surveillance Network (CPCSSN).
METHODS: This study used EMR data from 1,574 primary care providers in seven Canadian provinces, representing 689,301 patients.
Using a subset of patient records seven medical students or family medicine residents created a reference set of 1,772 patients.
A total of 23 clinician-informed case definitions were validated against the reference.
We assessed agreement using sensitivity (SE), specificity (SP), positive predictive value (PPV), negative predictive value (NPV) and overall accuracy.
The case definitions with the best agreement statistics were deployed to estimate the prevalence of eczema in the CPCSSN.
RESULTS: Case definition 1 had the highest SE (92.1%,85.0-96.5) but a lower SP (88.5%,86.7–90.1) and PPV (36.6%,33.1–40.3).
Case definition 7 was the most specific case definition with a SP (99.8%, 99.4–100) and PPV (84.2%,61.2–94.7) but low SE (15.8%,9.3–24.5).
Case definition 17 had a SE (75.3%, 65.7–83.3), SP (93.8%, 91.5–94.3) and PPV 43.7% (38.3–49.2).
When we applied the most specific and most sensitive case definitions, we estimate the prevalence of eczema to be between 0.8 and 15.1%.
Case definition 17 suggests an eczema prevalence estimate of 8.2% (8.08–8.21%).
CONCLUSIONS: We validated EMR-based eczema case definitions to estimate the prevalence of clinician-documented eczema.
Future studies may choose to apply one or more of these definitions’ dependent on their studies objectives to inform disease surveillance as well as explore burden of illness or interventions related to eczema care in Canada.
Stirton, Hannah,Kosowan, Leanne,Abrams, Elissa M,Protudjer, Jennifer LP,Queenan, John,Singer, Alexander, 2023, Validation of a primary care electronic medical records case definition for eczema: retrospective cross-sectional study, BioMed Central
Configurable Safety Tuning of Language Models with Synthetic Preference Data
data preference cst dpo configurable language safety
Affective flexibility as a developmental building block of cognitive reappraisal: An fMRI study
cognitive success affective flexibility
