Neuropsychiatric Features, Health-Related Quality of Life, and Caregiver Burden in Parkinson's Disease

AIM: Parkinson's disease (PD) is a progressive neurodegenerative disease and significantly impacts patients and their caregivers.

The current study aims at recognizing its neuropsychiatric symptoms, its impact on the health-related quality of life (HRQOL) of the patients, and the caregiver burden in a middle- to-low-income country.

METHODS: We conducted a cross-sectional survey of 73 idiopathic Parkinson's disease (IPD) patients and their caregivers from January 2021 to June 2021.

Neuropsychiatric Inventory (NPI-12) and Parkinson's disease questionnaire (PDQ-39) were used to assess patients' symptoms and HRQOL, respectively.

We used the Zarit caregiver burden interview (ZBI) and Hamilton depression scale (Ham-D) for the caregiver's burden assessment.

RESULTS: Of the 73 patients, 43 (59%) were men, and 30 (41%) were women.

Their mean age was 60.25 years (± 11.1), and the mean duration of PD was 6.4 years (± 3.4).

Eighty-six percent of the patients reported having one or more neuropsychiatric symptoms.

HRQOL, as indicated by PDQ-39, correlated most significantly with H and Y staging (r = 0.680, P < 0.001) of the disease.

Sixty-eight percent of the caregivers felt a disease burden, and 55% had depression.

On regression analysis, NPI total score on caregiver burden (beta = 0.883, P < 0.001, confidence interval [CI] of 1.087 to 1.400,) and H and Y staging on depression (beta = 0.772, P < 0.001, [CI of 0.629 to 0.934) were having the most decisive impact.

CONCLUSION: Our study showed the presence of frequent neuropsychiatric symptoms in PD patients.

It has a detrimental effect on the quality of life of patients and results in a significant increase in caregiver burden and depression among them.