Dokumentdetails
ID
oai:pubmedcentral.nih.gov:1024...
Thema
InterventionalAutor
Darsaut, T.E. Findlay, J.M. Bojanowski, M.W. Chalaala, C. Iancu, D. Roy, D. Weill, A. Boisseau, W. Diouf, A. Magro, E. Kotowski, M. Keough, M.B. Estrade, L. Bricout, N. Lejeune, J.-P. Chow, M.M.C. O’Kelly, C.J. Rempel, J.L. Ashforth, R.A. Lesiuk, H. Sinclair, J. Erdenebold, U.-E. Wong, J.H. Scholtes, F. Martin, D. Otto, B. Bilocq, A. Truffer, E. Butcher, K. Fox, A.J. Arthur, A.S. Létourneau-Guillon, L. Guilbert, F. Chagnon, M. Zehr, J. Farzin, B. Gevry, G. Raymond, J.Langue
enEditor
American Society of Neuroradiology
Kategorie
AJNR: American Journal of Neuroradiology
Jahr
2023
Auflistungsdatum
10.06.2024
Schlüsselwörter
surgical failure surgery risk primary outcome relative 95% ci treatment patients clipping aneurysms intracranial unruptured endovascularZusammenfassung
BACKGROUND AND PURPOSE: Surgical clipping and endovascular treatment are commonly used in patients with unruptured intracranial aneurysms.
We compared the safety and efficacy of the 2 treatments in a randomized trial.
MATERIALS AND METHODS: Clipping or endovascular treatments were randomly allocated to patients with one or more 3- to 25-mm unruptured intracranial aneurysms judged treatable both ways by participating physicians.
The study hypothesized that clipping would decrease the incidence of treatment failure from 13% to 4%, a composite primary outcome defined as failure of aneurysm occlusion, intracranial hemorrhage during follow-up, or residual aneurysms at 1 year, as adjudicated by a core lab.
Safety outcomes included new neurologic deficits following treatment, hospitalization of >5 days, and overall morbidity and mortality (mRS > 2) at 1 year.
There was no blinding.
RESULTS: Two hundred ninety-one patients were enrolled from 2010 to 2020 in 7 centers.
The 1-year primary outcome, ascertainable in 290/291 (99%) patients, was reached in 13/142 (9%; 95% CI, 5%–15%) patients allocated to surgery and in 28/148 (19%; 95% CI, 13%–26%) patients allocated to endovascular treatments (relative risk: 2.07; 95% CI, 1.12–3.83; P = .021).
Morbidity and mortality (mRS >2) at 1 year occurred in 3/143 and 3/148 (2%; 95% CI, 1%–6%) patients allocated to surgery and endovascular treatments, respectively.
Neurologic deficits (32/143, 22%; 95% CI, 16%–30% versus 19/148, 12%; 95% CI, 8%–19%; relative risk: 1.74; 95% CI, 1.04–2.92; P = .04) and hospitalizations beyond 5 days (69/143, 48%; 95% CI, 40%–56% versus 12/148, 8%; 95% CI, 5%–14%; relative risk: 0.18; 95% CI, 0.11–0.31; P < .001) were more frequent after surgery.
CONCLUSIONS: Surgical clipping is more effective than endovascular treatment of unruptured intracranial aneurysms in terms of the frequency of the primary outcome of treatment failure.
Results were mainly driven by angiographic results at 1 year.
Darsaut, T.E.,Findlay, J.M.,Bojanowski, M.W.,Chalaala, C.,Iancu, D.,Roy, D.,Weill, A.,Boisseau, W.,Diouf, A.,Magro, E.,Kotowski, M.,Keough, M.B.,Estrade, L.,Bricout, N.,Lejeune, J.-P.,Chow, M.M.C.,O’Kelly, C.J.,Rempel, J.L.,Ashforth, R.A.,Lesiuk, H.,Sinclair, J.,Erdenebold, U.-E.,Wong, J.H.,Scholtes, F.,Martin, D.,Otto, B.,Bilocq, A.,Truffer, E.,Butcher, K.,Fox, A.J.,Arthur, A.S.,Létourneau-Guillon, L.,Guilbert, F.,Chagnon, M.,Zehr, J.,Farzin, B.,Gevry, G.,Raymond, J., 2023, A Pragmatic Randomized Trial Comparing Surgical Clipping and Endovascular Treatment of Unruptured Intracranial Aneurysms, American Society of Neuroradiology
SliM-LLM: Salience-Driven Mixed-Precision Quantization for Large Language Models
methods salience efficiency quantization language slim-llm llms
Prediction Models for Suicide Attempts among Adolescents Using Machine Learning Techniques
using data ml prediction 0 suicide adolescents
