Dokumentdetails
ID
oai:pubmedcentral.nih.gov:1093...
Thema
Original StudyAutor
Bhatia, Divya Mehta, Hitaishi Bishnoi, Anuradha Srivastava, Niharika Vinay, Keshavamurthy Parsad, Davinder Kumaran, Muthu SendhilLangue
enEditor
Lippincott Williams & Wilkins
Kategorie
Asia Pacific Allergy
Jahr
2024
Auflistungsdatum
25.03.2024
Schlüsselwörter
nonresponders responders significantly anti-tpo baseline study antihistamine response 0 levels patients urticaria il-9 a-iv apo disease serum severity biomarkersZusammenfassung
BACKGROUND: Role of complement fraction 5a (C5a), interleukin (IL)-9, and apolipoprotein (apo) A-IV as biomarkers of disease severity and antihistamine response in chronic spontaneous urticaria (CSU) remains elusive.
OBJECTIVE: To identify the role of C5a, IL-9, and apo A-IV as potential biomarkers in predicting disease severity and antihistamine response in CSU patients.
METHODS: This was a prospective observational study of 95 patients and 42 controls.
Serum analysis of C5a, IL-9, and apo A-IV was done using enyzme linked immunosorbent assay kits.
Also, serum IgE and anti-thyroid peroxidase (TPO) levels were assessed in all patients.
All patients were started on oral levocetirizine 5 mg at baseline and dose was titrated upwards to maximum of 20 mg based on response.
Patients were categorized into antihistamine responders or nonresponders as per their disease response.
Serological markers, serum IgE, and anti-TPO were correlated with baseline disease severity and antihistamine response.
RESULTS: C5a levels were significantly higher in cases as compared to controls (P = 0.004).
Significantly higher IL-9 levels were observed in antihistamine responders than nonresponders (P = 0.008).
Baseline urticaria severity demonstrated a statistically significant positive and negative correlations with IL-9 (ρ = 0.277, P = 0.007) and apo A-IV (ρ = −0.271, P = 0.008) levels, respectively.
Levels of serum IgE (P = 0.031) and anti-TPO (P = 0.039) were significantly higher in antihistamine nonresponders compared to responders.
CONCLUSIONS: IL-9 and apo A-IV might be potential novel biomarkers to predict urticaria severity.
Higher IL-9 might be a predictor of antihistamine response.
Elevated anti-TPO and serum IgE might predict poor antihistamine response.
Bhatia, Divya,Mehta, Hitaishi,Bishnoi, Anuradha,Srivastava, Niharika,Vinay, Keshavamurthy,Parsad, Davinder,Kumaran, Muthu Sendhil, 2024, A prospective observational study correlating possible novel biomarkers with disease severity and antihistamine response in chronic spontaneous urticaria, Lippincott Williams & Wilkins
Configurable Safety Tuning of Language Models with Synthetic Preference Data
data preference cst dpo configurable language safety
Affective flexibility as a developmental building block of cognitive reappraisal: An fMRI study
cognitive success affective flexibility
