Dokumentdetails
ID
oai:pubmedcentral.nih.gov:9627...
Thema
Original ArticlesAutor
Chen, Lili Wang, Junling Xia, Mingrui Sun, Lianglong Sun, Junyan Gao, Linlin Zhang, Dongling Wu, TaoLangue
enEditor
John Wiley and Sons Inc.
Kategorie
CNS Neuroscience & Therapeutics
Jahr
2022
Auflistungsdatum
12.12.2022
Schlüsselwörter
network associated parkinson shell core fc changes subregions leftZusammenfassung
AIMS: This study aimed to identify the functional connectivity (FC) changes of nucleus accumbens (NAc) subregions and characterize the association of network changes and non‐motor symptoms (NMS) in Parkinson's disease (PD).
METHODS: We enrolled 129 PD patients and 106 healthy controls from our center and the PPMI (Parkinson's Progression Markers Initiative) database.
The FC of the bilateral core and shell of the NAc were measured and compared between the two groups.
We further used partial least squares correlation to reveal the relationships between altered FC of NAc subregions and manifestations of NMS of PD.
RESULTS: The subregions of left core, left shell, and right core had reduced FC with extensive brain regions in PD patients compared with healthy controls.
These three subregions were commonly associated with depression, anxiety, apathy, and cognitive impairment.
Moreover, the left core and left shell were associated with excessive daytime sleepiness, whereas the right core was associated with olfactory impairment and rapid eye movement sleep behavior disorder.
CONCLUSION: This study for the first time identified the neural network changes of NAc subregions in PD and the associations between network changes and phenotypes of NMS.
Our findings provide new insights into the pathogenesis of NMS in PD.
Chen, Lili,Wang, Junling,Xia, Mingrui,Sun, Lianglong,Sun, Junyan,Gao, Linlin,Zhang, Dongling,Wu, Tao, 2022, Altered functional connectivity of nucleus accumbens subregions associates with non‐motor symptoms in Parkinson's disease, John Wiley and Sons Inc.
Configurable Safety Tuning of Language Models with Synthetic Preference Data
data preference cst dpo configurable language safety
Affective flexibility as a developmental building block of cognitive reappraisal: An fMRI study
cognitive success affective flexibility
