Dokumentdetails
ID
oai:pubmedcentral.nih.gov:1007...
Thema
Original ArticleAutor
Xie, Taorong Huang, Can Zhang, Yijie Liu, Jing Yao, HaishanLangue
enEditor
Springer Nature Singapore
Kategorie
Neuroscience Bulletin
Jahr
2022
Auflistungsdatum
03.04.2024
Schlüsselwörter
alm trial recent interval timingZusammenfassung
Interval timing is involved in a variety of cognitive behaviors such as associative learning and decision-making.
While it has been shown that time estimation is adaptive to the temporal context, it remains unclear how interval timing behavior is influenced by recent trial history.
Here we found that, in mice trained to perform a licking-based interval timing task, a decrease of inter-reinforcement interval in the previous trial rapidly shifted the time of anticipatory licking earlier.
Optogenetic inactivation of the anterior lateral motor cortex (ALM), but not the medial prefrontal cortex, for a short time before reward delivery caused a decrease in the peak time of anticipatory licking in the next trial.
Electrophysiological recordings from the ALM showed that the response profiles preceded by short and long inter-reinforcement intervals exhibited task-engagement-dependent temporal scaling.
Thus, interval timing is adaptive to recent experience of the temporal interval, and ALM activity during time estimation reflects recent experience of interval.
SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12264-022-00954-2.
Xie, Taorong,Huang, Can,Zhang, Yijie,Liu, Jing,Yao, Haishan, 2022, Influence of Recent Trial History on Interval Timing, Springer Nature Singapore
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