Dokumentdetails
ID
oai:pubmedcentral.nih.gov:1046...
Thema
Original ArticleAutor
Zhang, Yuxing Zhao, Xin Guo, Chun Zhang, Ying Zeng, Fukang Yin, Qian Li, Zhong Shao, Le Zhou, Desheng Liu, LijuanLangue
enEditor
Springer Nature Singapore
Kategorie
Neuroscience Bulletin
Jahr
2023
Auflistungsdatum
04.09.2024
Schlüsselwörter
protein stroke ischemic pathway circadianZusammenfassung
Ischemic stroke is a major public health problem worldwide.
Although the circadian clock is involved in the process of ischemic stroke, the exact mechanism of the circadian clock in regulating angiogenesis after cerebral infarction remains unclear.
In the present study, we determined that environmental circadian disruption (ECD) increased the stroke severity and impaired angiogenesis in the rat middle cerebral artery occlusion model, by measuring the infarct volume, neurological tests, and angiogenesis-related protein.
We further report that Bmal1 plays an irreplaceable role in angiogenesis.
Overexpression of Bmal1 promoted tube-forming, migration, and wound healing, and upregulated the vascular endothelial growth factor (VEGF) and Notch pathway protein levels.
This promoting effect was reversed by the Notch pathway inhibitor DAPT, according to the results of angiogenesis capacity and VEGF pathway protein level.
In conclusion, our study reveals the intervention of ECD in angiogenesis in ischemic stroke and further identifies the exact mechanism by which Bmal1 regulates angiogenesis through the VEGF-Notch1 pathway.
Zhang, Yuxing,Zhao, Xin,Guo, Chun,Zhang, Ying,Zeng, Fukang,Yin, Qian,Li, Zhong,Shao, Le,Zhou, Desheng,Liu, Lijuan, 2023, The Circadian System Is Essential for the Crosstalk of VEGF-Notch-mediated Endothelial Angiogenesis in Ischemic Stroke, Springer Nature Singapore
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