Dokumentdetails
ID
oai:pubmedcentral.nih.gov:1060...
Thema
Original ArticleAutor
Song, Changgeng Zhao, Yan Zhang, Jiajia Dong, Ziyi Kang, Xin Pan, Yuqi Du, Jinle Gao, Yiting Zhang, Haifeng Xi, Ye Ding, Hui Kuang, Fang Wang, Wenting Luo, Ceng Zhang, Zhengping Zhao, Qinpeng Yang, Jiazhou Jiang, Wen Wu, Shengxi Gao, FangLangue
enEditor
Springer Nature Singapore
Kategorie
Neuroscience Bulletin
Jahr
2023
Auflistungsdatum
06.11.2024
Schlüsselwörter
interneurons alterations distribution parvalbuminZusammenfassung
Parvalbumin interneurons belong to the major types of GABAergic interneurons.
Although the distribution and pathological alterations of parvalbumin interneuron somata have been widely studied, the distribution and vulnerability of the neurites and fibers extending from parvalbumin interneurons have not been detailly interrogated.
Through the Cre recombinase-reporter system, we visualized parvalbumin-positive fibers and thoroughly investigated their spatial distribution in the mouse brain.
We found that parvalbumin fibers are widely distributed in the brain with specific morphological characteristics in different regions, among which the cortex and thalamus exhibited the most intense parvalbumin signals.
In regions such as the striatum and optic tract, even long-range thick parvalbumin projections were detected.
Furthermore, in mouse models of temporal lobe epilepsy and Parkinson’s disease, parvalbumin fibers suffered both massive and subtle morphological alterations.
Our study provides an overview of parvalbumin fibers in the brain and emphasizes the potential pathological implications of parvalbumin fiber alterations.
SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12264-023-01083-0.
Song, Changgeng,Zhao, Yan,Zhang, Jiajia,Dong, Ziyi,Kang, Xin,Pan, Yuqi,Du, Jinle,Gao, Yiting,Zhang, Haifeng,Xi, Ye,Ding, Hui,Kuang, Fang,Wang, Wenting,Luo, Ceng,Zhang, Zhengping,Zhao, Qinpeng,Yang, Jiazhou,Jiang, Wen,Wu, Shengxi,Gao, Fang, 2023, Spatial Distribution of Parvalbumin-Positive Fibers in the Mouse Brain and Their Alterations in Mouse Models of Temporal Lobe Epilepsy and Parkinson’s Disease, Springer Nature Singapore
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