Dokumentdetails
ID
oai:pubmedcentral.nih.gov:1125...
Thema
ReviewAutor
Ma, Xiangyu Guo, Jiamin Tian, Mengyao Fu, Yaoyang Jiang, Pei Zhang, Yuan Chai, RenjieLangue
enEditor
Springer Nature Singapore
Kategorie
Neuroscience Bulletin
Jahr
2023
Auflistungsdatum
24.07.2024
Zusammenfassung
Hearing loss and deafness, as a worldwide disability disease, have been troubling human beings.
However, the auditory organ of the inner ear is highly heterogeneous and has a very limited number of cells, which are largely uncharacterized in depth.
Recently, with the development and utilization of single-cell RNA sequencing (scRNA-seq), researchers have been able to unveil the complex and sophisticated biological mechanisms of various types of cells in the auditory organ at the single-cell level and address the challenges of cellular heterogeneity that are not resolved through by conventional bulk RNA sequencing (bulk RNA-seq).
Herein, we reviewed the application of scRNA-seq technology in auditory research, with the aim of providing a reference for the development of auditory organs, the pathogenesis of hearing loss, and regenerative therapy.
Prospects about spatial transcriptomic scRNA-seq, single-cell based genome, and Live-seq technology will also be discussed.
Ma, Xiangyu,Guo, Jiamin,Tian, Mengyao,Fu, Yaoyang,Jiang, Pei,Zhang, Yuan,Chai, Renjie, 2023, Advance and Application of Single-cell Transcriptomics in Auditory Research, Springer Nature Singapore
