detalle del documento
IDENTIFICACIÓN
doi:10.1186/s12953-023-00205-w...
Autor
Fu, Wenrui Xie, Zifeng Bai, Mei Zhang, Zhen Zhao, Yuanlong Tian, JingLangue
enEditor
BioMed Central
Categoría
Life Sciences
Año
2023
fecha de cotización
12/4/2023
Palabras clave
macrophage menk proteomics analysis polarization phagosome influenza deps proteins proteomics virus macrophages menkResumen
Macrophages have a vital role in phagocytosis and antiviral effect against invading influenza viruses.
Previously, we found that methionine enkephalin (MENK) inhibited influenza virus infection by upregulating the “antiviral state” of macrophages.
To investigate the immunoregulatory mechanism of action of MENK on macrophages, we employed proteomic analysis to identify differentially expressed proteins (DEPs) between macrophages infected with the influenza-A virus and cells infected with the influenza-A virus after pretreatment with MENK.
A total of 215 DEPs were identified: 164 proteins had upregulated expression and 51 proteins had downregulated expression.
Proteomics analysis showed that DEPs were highly enriched in “cytokine-cytokine receptor interaction”, “phagosome”, and “complement and coagulation cascades pathway”.
Proteomics analysis revealed that MENK could be an immune modulator or prophylactic for the prevention and treatment of influenza.
MENK promoted the polarization of M1 macrophages, activated inflammatory responses, and enhanced phagocytosis and killing function by upregulating opsonizing receptors.
Fu, Wenrui,Xie, Zifeng,Bai, Mei,Zhang, Zhen,Zhao, Yuanlong,Tian, Jing, 2023, Proteomics analysis of methionine enkephalin upregulated macrophages against infection by the influenza-A virus, BioMed Central
Utility of Photon-Counting Detector CT Myelography for the Detection of CSF-Venous Fistulas
imaging photon-counting myelography
