detalle del documento
IDENTIFICACIÓN
doi:10.1186/s13578-023-00995-8...
Autor
Zhou, Zhihang Yang, Zihan Zhou, Li Yang, Mengsu He, SongLangue
enEditor
BioMed Central
Categoría
Life Sciences
Año
2023
fecha de cotización
22/3/2023
Palabras clave
tetraspanin cancer metastasis extracellular vesicles immunonology membrane cancer proteins cellResumen
The tetraspanins (TSPANs) are a family of four-transmembrane proteins with 33 members in mammals.
They are variably expressed on the cell surface, various intracellular organelles and vesicles in nearly all cell types.
Different from the majority of cell membrane proteins, TSPANs do not have natural ligands.
TSPANs typically organize laterally with other membrane proteins to form tetraspanin-enriched microdomains (TEMs) to influence cell adhesion, migration, invasion, survival and induce downstream signaling.
Emerging evidence shows that TSPANs can regulate not only cancer cell growth, metastasis, stemness, drug resistance, but also biogenesis of extracellular vesicles (exosomes and migrasomes), and immunomicroenvironment.
This review summarizes recent studies that have shown the versatile function of TSPANs in cancer development and progression, or the molecular mechanism of TSPANs.
These findings support the potential of TSPANs as novel therapeutic targets against cancer.
Zhou, Zhihang,Yang, Zihan,Zhou, Li,Yang, Mengsu,He, Song, 2023, The versatile roles of testrapanins in cancer from intracellular signaling to cell–cell communication: cell membrane proteins without ligands, BioMed Central
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