detalle del documento
IDENTIFICACIÓN
doi:10.1007/s12672-024-00867-8...
Autor
Wang, Juanjing Peng, Junmei Chen, Yonglin Nasser, M. I. Qin, HuiLangue
enEditor
Springer
Categoría
Medicine & Public Health
Año
2024
fecha de cotización
24/1/2024
Palabras clave
emt tumor metastasis tumor microenvironments stromal cells secretions stromal cancer emtResumen
The epithelial–mesenchymal transition (EMT) is a critical tumor invasion and metastasis process.
EMT enables tumor cells to migrate, detach from their original location, enter the circulation, circulate within it, and eventually exit from blood arteries to colonize in foreign sites, leading to the development of overt metastases, ultimately resulting in death.
EMT is intimately tied to stromal cells around the tumor and is controlled by a range of cytokines secreted by stromal cells.
This review summarizes recent research on stromal cell-mediated EMT in tumor invasion and metastasis.
We also discuss the effects of various stromal cells on EMT induction and focus on the molecular mechanisms by which several significant stromal cells convert from foes to friends of cancer cells to fuel EMT processes via their secretions in the tumor microenvironment (TME).
As a result, a better knowledge of the role of stromal cells in cancer cells’ EMT may pave the path to cancer eradication.
Wang, Juanjing,Peng, Junmei,Chen, Yonglin,Nasser, M. I.,Qin, Hui, 2024, The role of stromal cells in epithelial–mesenchymal plasticity and its therapeutic potential, Springer
Utility of Photon-Counting Detector CT Myelography for the Detection of CSF-Venous Fistulas
imaging photon-counting myelography
