The single-cell opioid responses in the context of HIV (SCORCH) consortium

Ament, Seth A.; Campbell, Rianne R.; Lobo, Mary Kay; Receveur, Joseph P.; Agrawal, Kriti; Borjabad, Alejandra; Byrareddy, Siddappa N.; Chang, Linda; Clarke, Declan; Emani, Prashant; Gabuzda, Dana; Gaulton, Kyle J.; Giglio, Michelle; Giorgi, Federico M.; Gok, Busra; Guda, Chittibabu; Hadas, Eran; Herb, Brian R.; Hu, Wen; Huttner, Anita; Ishmam, Mohammad R.; Jacobs, Michelle M.; Kelschenbach, Jennifer; Kim, Dong-Wook; Lee, Cheyu; Liu, Shuhui; Liu, Xiaokun; Madras, Bertha K.; Mahurkar, Anup A.; Mash, Deborah C.; Mukamel, Eran A.; Niu, Meng; O’Connor, Richard M.; Pagan, Chelsea M.; Pang, Alina P. S.; Pillai, Piya; Repunte-Canonigo, Vez; Ruzicka, W. Brad; Stanley, Jay; Tickle, Timothy; Tsai, Shang-Yi A.; Wang, Allen; Wills, Lauren; Wilson, Alyssa M.; Wright, Susan N.; Xu, Siwei; Yang, Junchen; Zand, Maryam; Zhang, Le; Zhang, Jing; Akbarian, Schahram; Buch, Shilpa; Cheng, Christine S.; Corley, Michael J.; Fox, Howard S.; Gerstein, Mark; Gummuluru, Suryaram; Heiman, Myriam; Ho, Ya-Chi; Kellis, Manolis; Kenny, Paul J.; Kluger, Yuval; Milner, Teresa A.; Moore, David J.; Morgello, Susan; Ndhlovu, Lishomwa C.; Rana, Tariq M.; Sanna, Pietro Paolo; Satterlee, John S.; Sestan, Nenad; Spector, Stephen A.; Spudich, Serena; Tilgner, Hagen U.; Volsky, David J.; White, Owen R.; Williams, Dionne W.; Zeng, Hongkui

doi:10.1038/s41380-024-02620-7

The single-cell opioid responses in the context of HIV (SCORCH) consortium

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IDENTIFICACIÓN

doi:10.1038/s41380-024-02620-7...

Autor

Ament, Seth A. Campbell, Rianne R. Lobo, Mary Kay Receveur, Joseph P. Agrawal, Kriti Borjabad, Alejandra Byrareddy, Siddappa N. Chang, Linda Clarke, Declan Emani, Prashant Gabuzda, Dana Gaulton, Kyle J. Giglio, Michelle Giorgi, Federico M. Gok, Busra Guda, Chittibabu Hadas, Eran Herb, Brian R. Hu, Wen Huttner, Anita Ishmam, Mohammad R. Jacobs, Michelle M. Kelschenbach, Jennifer Kim, Dong-Wook Lee, Cheyu Liu, Shuhui Liu, Xiaokun Madras, Bertha K. Mahurkar, Anup A. Mash, Deborah C. Mukamel, Eran A. Niu, Meng O’Connor, Richard M. Pagan, Chelsea M. Pang, Alina P. S. Pillai, Piya Repunte-Canonigo, Vez Ruzicka, W. Brad Stanley, Jay Tickle, Timothy Tsai, Shang-Yi A. Wang, Allen Wills, Lauren Wilson, Alyssa M. Wright, Susan N. Xu, Siwei Yang, Junchen Zand, Maryam Zhang, Le Zhang, Jing Akbarian, Schahram Buch, Shilpa Cheng, Christine S. Corley, Michael J. Fox, Howard S. Gerstein, Mark Gummuluru, Suryaram Heiman, Myriam Ho, Ya-Chi Kellis, Manolis Kenny, Paul J. Kluger, Yuval Milner, Teresa A. Moore, David J. Morgello, Susan Ndhlovu, Lishomwa C. Rana, Tariq M. Sanna, Pietro Paolo Satterlee, John S. Sestan, Nenad Spector, Stephen A. Spudich, Serena Tilgner, Hagen U. Volsky, David J. White, Owen R. Williams, Dionne W. Zeng, Hongkui

Langue

Editor

Nature

Categoría

Medicine & Public Health

Año

2024

fecha de cotización

19/6/2024

Palabras clave

risk addiction brain effects single-cell hiv

Métrico

Resumen

Substance use disorders (SUD) and drug addiction are major threats to public health, impacting not only the millions of individuals struggling with SUD, but also surrounding families and communities.

One of the seminal challenges in treating and studying addiction in human populations is the high prevalence of co-morbid conditions, including an increased risk of contracting a human immunodeficiency virus (HIV) infection.

Of the ~15 million people who inject drugs globally, 17% are persons with HIV.

Conversely, HIV is a risk factor for SUD because chronic pain syndromes, often encountered in persons with HIV, can lead to an increased use of opioid pain medications that in turn can increase the risk for opioid addiction.

We hypothesize that SUD and HIV exert shared effects on brain cell types, including adaptations related to neuroplasticity, neurodegeneration, and neuroinflammation.

Basic research is needed to refine our understanding of these affected cell types and adaptations.

Studying the effects of SUD in the context of HIV at the single-cell level represents a compelling strategy to understand the reciprocal interactions among both conditions, made feasible by the availability of large, extensively-phenotyped human brain tissue collections that have been amassed by the Neuro-HIV research community.

In addition, sophisticated animal models that have been developed for both conditions provide a means to precisely evaluate specific exposures and stages of disease.

We propose that single-cell genomics is a uniquely powerful technology to characterize the effects of SUD and HIV in the brain, integrating data from human cohorts and animal models.

We have formed the Single-Cell Opioid Responses in the Context of HIV (SCORCH) consortium to carry out this strategy.

Ament, Seth A.,Campbell, Rianne R.,Lobo, Mary Kay,Receveur, Joseph P.,Agrawal, Kriti,Borjabad, Alejandra,Byrareddy, Siddappa N.,Chang, Linda,Clarke, Declan,Emani, Prashant,Gabuzda, Dana,Gaulton, Kyle J.,Giglio, Michelle,Giorgi, Federico M.,Gok, Busra,Guda, Chittibabu,Hadas, Eran,Herb, Brian R.,Hu, Wen,Huttner, Anita,Ishmam, Mohammad R.,Jacobs, Michelle M.,Kelschenbach, Jennifer,Kim, Dong-Wook,Lee, Cheyu,Liu, Shuhui,Liu, Xiaokun,Madras, Bertha K.,Mahurkar, Anup A.,Mash, Deborah C.,Mukamel, Eran A.,Niu, Meng,O’Connor, Richard M.,Pagan, Chelsea M.,Pang, Alina P. S.,Pillai, Piya,Repunte-Canonigo, Vez,Ruzicka, W. Brad,Stanley, Jay,Tickle, Timothy,Tsai, Shang-Yi A.,Wang, Allen,Wills, Lauren,Wilson, Alyssa M.,Wright, Susan N.,Xu, Siwei,Yang, Junchen,Zand, Maryam,Zhang, Le,Zhang, Jing,Akbarian, Schahram,Buch, Shilpa,Cheng, Christine S.,Corley, Michael J.,Fox, Howard S.,Gerstein, Mark,Gummuluru, Suryaram,Heiman, Myriam,Ho, Ya-Chi,Kellis, Manolis,Kenny, Paul J.,Kluger, Yuval,Milner, Teresa A.,Moore, David J.,Morgello, Susan,Ndhlovu, Lishomwa C.,Rana, Tariq M.,Sanna, Pietro Paolo,Satterlee, John S.,Sestan, Nenad,Spector, Stephen A.,Spudich, Serena,Tilgner, Hagen U.,Volsky, David J.,White, Owen R.,Williams, Dionne W.,Zeng, Hongkui, 2024, The single-cell opioid responses in the context of HIV (SCORCH) consortium, Nature