Dual trajectories of antiretroviral therapy adherence and polypharmacy in women with HIV in the United States

Elbur, Abubaker Ibrahim; Ghebremichael, Musie; Konkle-Parker, Deborah; Jones, Deborah L; Collins, Shelby; Adimora, Adaora A.; Schneider, Michael F.; Cohen, Mardge H.; Tamraz, Bani; Plankey, Michael; Wilson, Tracey; Adedimeji, Adebola; Haberer, Jessica E.; Jacobson, Denise L.

doi:10.1186/s12981-023-00520-4

Dual trajectories of antiretroviral therapy adherence and polypharmacy in women with HIV in the United States

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IDENTIFICACIÓN

doi:10.1186/s12981-023-00520-4...

Autor

Elbur, Abubaker Ibrahim Ghebremichael, Musie Konkle-Parker, Deborah Jones, Deborah L Collins, Shelby Adimora, Adaora A. Schneider, Michael F. Cohen, Mardge H. Tamraz, Bani Plankey, Michael Wilson, Tracey Adedimeji, Adebola Haberer, Jessica E. Jacobson, Denise L.

Langue

Editor

BioMed Central

Categoría

Medicine & Public Health

Año

2023

fecha de cotización

17/5/2023

Palabras clave

hiv identify gbtm

Métrico

Resumen

Background Polypharmacy, using five or more medications, may increase the risk of nonadherence to prescribed treatment.

We aimed to identify the interrelationship between trajectories of adherence to antiretroviral therapy (ART) and polypharmacy.

Methods We included women with HIV (aged ≥ 18) enrolled in the Women’s Interagency HIV Study in the United States from 2014 to 2019.

We used group-based trajectory modeling (GBTM) to identify trajectories of adherence to ART and polypharmacy and the dual GBTM to identify the interrelationship between adherence and polypharmacy.

Results Overall, 1,538 were eligible (median age of 49 years).

GBTM analysis revealed five latent trajectories of adherence with 42% of women grouped in the consistently moderate trajectory.

GBTM identified four polypharmacy trajectories with 45% categorized in the consistently low group.

Conclusions The joint model did not reveal any interrelationship between ART adherence and polypharmacy trajectories.

Future research should consider examining the interrelationship between both variables using objective measures of adherence.

Elbur, Abubaker Ibrahim,Ghebremichael, Musie,Konkle-Parker, Deborah,Jones, Deborah L,Collins, Shelby,Adimora, Adaora A.,Schneider, Michael F.,Cohen, Mardge H.,Tamraz, Bani,Plankey, Michael,Wilson, Tracey,Adedimeji, Adebola,Haberer, Jessica E.,Jacobson, Denise L., 2023, Dual trajectories of antiretroviral therapy adherence and polypharmacy in women with HIV in the United States, BioMed Central