detalle del documento
IDENTIFICACIÓN
doi:10.1186/s43046-024-00220-8...
Autor
Kouchaki, Hosein Kamyab, Parnia Darbeheshti, Farzaneh Gharezade, Arezou Fouladseresht, Hamed Tabrizi, RezaLangue
enEditor
Springer
Categoría
Medicine & Public Health
Año
2024
fecha de cotización
1/5/2024
Palabras clave
mir-939 cancer diagnostic prognostic therapeutic target cancer mir-939Resumen
Background MicroRNAs (miRNAs or miRs) are highly conserved non-coding RNAs with a short length (18–24 nucleotides) that directly bind to a complementary sequence within 3′-untranslated regions of their target mRNAs and regulate gene expression, post-transcriptionally.
They play crucial roles in diverse biological processes, including cell proliferation, apoptosis, and differentiation.
In the context of cancer, miRNAs are key regulators of growth, angiogenesis, metastasis, and drug resistance.
Main body This review primarily focuses on miR-939 and its expanding roles and target genes in cancer pathogenesis.
It compiles findings from various investigations.
MiRNAs, due to their dysregulated expression in tumor environments, hold potential as cancer biomarkers.
Several studies have highlighted the dysregulation of miR-939 expression in human cancers.
Conclusion Our study highlights the potential of miR-939 as a valuable target in cancer diagnosis, prognosis, and treatment.
The aberrant expression of miR-939, along with other miRNAs, underscores their significance in advancing our understanding of cancer biology and their promise in personalized cancer care.
Kouchaki, Hosein,Kamyab, Parnia,Darbeheshti, Farzaneh,Gharezade, Arezou,Fouladseresht, Hamed,Tabrizi, Reza, 2024, miR-939, as an important regulator in various cancers pathogenesis, has diagnostic, prognostic, and therapeutic values: a review, Springer
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