detalle del documento
IDENTIFICACIÓN
doi:10.1007/s00467-024-06425-2...
Autor
Svabova, Eva Zieg, Jakub Sukova, Martina Flachsova, Eva Kment, Martin Tesar, VladimirLangue
enEditor
Springer
Categoría
Urology
Año
2024
fecha de cotización
12/6/2024
Palabras clave
adolescent daratumumab proliferative glomerulonephritis w... proteinuria deposits daratumumabResumen
There is no specific treatment for proliferative glomerulonephritis with monoclonal IgG deposits (PGNMID), a disease that is very rare in the pediatric population.
We report the case of a 15-year-old boy who presented with mildly reduced kidney function and nephrotic syndrome.
Kidney biopsy revealed PGNMID with monoclonal deposits of IgG3 with kappa light chain restriction.
Flow cytometry showed a significant CD38 plasma cell population in the peripheral blood in the absence of other signs of hematological malignancy.
The patient was treated with a 6-month course of daratumumab, a monoclonal antibody targeting CD38.
There was a significant reduction in proteinuria and normalization of kidney function.
Based on positive experience with adults, daratumumab should also be studied in children with PGNMID.
Svabova, Eva,Zieg, Jakub,Sukova, Martina,Flachsova, Eva,Kment, Martin,Tesar, Vladimir, 2024, Proliferative glomerulonephritis with monoclonal IgG deposits in an adolescent successfully treated with daratumumab, Springer
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