detalle del documento
IDENTIFICACIÓN

doi:10.1007/s11255-024-03972-3...

Autor
Bossola, Maurizio Mariani, Ilaria Sacco, Monica Antocicco, Manuela Pepe, Gilda Stasio, Enrico
Langue
en
Editor

Springer

Categoría

Urology

Año

2024

fecha de cotización

13/3/2024

Palabras clave
hemodialysis hemodiafiltration sodium dialysate concentration interdialytic weight gain review systematic reduction quality included interdialytic gain weight sodium dialysate concentration idwg cross-over chronic hemodialysis patients low
Métrico

Resumen

Purpose The present systematic review and meta-analysis aimed at evaluating the effect of low dialysate sodium concentration on interdialytic weight gain (IDWG) in chronic hemodialysis patients.

Methods Studies were eligible for inclusion if they were English language papers published in a peer-reviewed journal and met the following inclusion criteria: (1) studies in adult patients (over 18 years of age), (2) included patients on chronic hemodialysis since at least 6 months; (3) compared standard (138–140 mmol/l) or high (> 140 mmol/l) dialysate sodium concentration with low (< 138 mmol/l) dialysate sodium concentration; (4) Included one outcome of interest: interdialytic weight gain.

Medline, PubMed, Web of Science, and the Cochrane Library were searched for the quality of reporting for each study was performed using the Quality Assessment Tool of Controlled Intervention Studies of the National Institutes of Health.

The quality of reporting of each cross-over study was performed using the Revised Cochrane Risk of Bias (RoB) tool for cross-over trials as proposed by Ding et al.

Results Nineteen studies (710 patients) were included in the analysis: 15 were cross-over and 4 parallel randomized controlled studies.

In cross-over studies, pooled analysis revealed that dialysate sodium concentration reduced IDWG with a pooled MD of − 0.40 kg (95% CI − 0.50 to − 0.30; p  < 0.001).

The systematic review of four parallel, randomized, studies revealed that the use of a low dialysate sodium concentration was associated with a significant reduction of the IDWG in two studies, sustained and almost significant ( p  = 0.05) reduction in one study, and not significant reduction in one study.

Conclusion Low dialysate sodium concentration reduces the IDWG in prevalent patients on chronic hemodialysis.

Bossola, Maurizio,Mariani, Ilaria,Sacco, Monica,Antocicco, Manuela,Pepe, Gilda,Stasio, Enrico, 2024, Interdialytic weight gain and low dialysate sodium concentration in patients on chronic hemodialysis: a systematic review and meta-analysis, Springer

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