Trajectories of body mass index in adulthood and all-cause and cause-specific mortality in the Melbourne Collaborative Cohort Study

Yang, Yi; Dugué, Pierre-Antoine; Lynch, Brigid M; Hodge, Allison M; Karahalios, Amalia; MacInnis, Robert J; Milne, Roger L; Giles, Graham G; English, Dallas R

Trajectories of body mass index in adulthood and all-cause and cause-specific mortality in the Melbourne Collaborative Cohort Study

detalle del documento

IDENTIFICACIÓN

oai:pubmedcentral.nih.gov:6701...

Tema

Epidemiology

Autor

Yang, Yi Dugué, Pierre-Antoine Lynch, Brigid M Hodge, Allison M Karahalios, Amalia MacInnis, Robert J Milne, Roger L Giles, Graham G English, Dallas R

Langue

Editor

BMJ Publishing Group

Categoría

BMJ Open

Año

2019

fecha de cotización

14/12/2023

Palabras clave

study lower-normal melbourne cohort associated class normal overweight trajectories mortality adulthood obesity hr 0 ci 95%

Métrico

Resumen

OBJECTIVE: Limited research has assessed the association between patterns of body mass index (BMI) change across adulthood and mortality.

We aimed to identify groups of individuals who followed specific group-based BMI trajectories across adulthood, using weight collected on three occasions and recalled data from early adulthood, and to examine associations with all-cause and cause-specific mortality.

DESIGN: Prospective cohort study.

SETTING: Melbourne, Australia.

PARTICIPANTS: Adults (n=29 881) enrolled in the Melbourne Collaborative Cohort Study, who were aged from 40 to 70 years between 1990 and 1994, and had BMI data for at least three time points.

OUTCOME: Deaths from any cause before 31 March 2017 and deaths from obesity-related cancers, cardiovascular diseases (CVDs) and other causes before 31 December 2013.

RESULTS: We identified six group-based BMI trajectories: lower-normal stable (TR1), higher-normal stable (TR2), normal to overweight (TR3), chronic borderline obesity (TR4), normal to class I obesity (TR5) and overweight to class II obesity (TR6).

Generally, compared with maintaining lower-normal BMI throughout adulthood, the lowest mortality was experienced by participants who maintained higher-normal BMI (HR 0.90; 95% CI 0.84 to 0.97); obesity during midlife was associated with higher all-cause mortality even when BMI was normal in early adulthood (HR 1.09; 95% CI 0.98 to 1.21) and prolonged borderline obesity from early adulthood was also associated with elevated mortality (HR 1.16; 95% CI 1.01 to 1.33).

These associations were stronger for never-smokers and for death due to obesity-related cancers.

Being overweight in early adulthood and becoming class II obese was associated with higher CVD mortality relative to maintaining lower-normal BMI (HR 2.27; 95% CI 1.34 to 3.87).

CONCLUSION: Our findings highlight the importance of weight management throughout adulthood to reduce mortality.

Yang, Yi,Dugué, Pierre-Antoine,Lynch, Brigid M,Hodge, Allison M,Karahalios, Amalia,MacInnis, Robert J,Milne, Roger L,Giles, Graham G,English, Dallas R, 2019, Trajectories of body mass index in adulthood and all-cause and cause-specific mortality in the Melbourne Collaborative Cohort Study, BMJ Publishing Group