detalle del documento
IDENTIFICACIÓN
oai:pubmedcentral.nih.gov:9907...
Tema
Major ArticleAutor
Gaglani, Manjusha Kim, Sara S Naleway, Allison L Levine, Min Z Edwards, Laura Murthy, Kempapura Dunnigan, Kayan Zunie, Tnelda Groom, Holly Ball, Sarah Jeddy, Zuha Hunt, Danielle Wesley, Meredith G Sambhara, Suryaprakash Gangappa, Shivaprakash Grant, Lauren Cao, Weiping Gross, F Liaini Mishina, Margarita Fry, Alicia M Thompson, Mark G Dawood, Fatimah S Flannery, BrendanLangue
enEditor
Oxford University Press
Categoría
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Año
2022
fecha de cotización
15/2/2023
Palabras clave
iiv/iiv randomized titers ratios y2 gmt cciiv/riv quadrivalent compared influenza immunogenicity consecutive hcp vaccineResumen
BACKGROUND: Antibody responses to non–egg-based standard-dose cell-culture influenza vaccine (containing 15 µg hemagglutinin [HA]/component) and recombinant vaccine (containing 45 µg HA/component) during consecutive seasons have not been studied in the United States.
METHODS: In a randomized trial of immunogenicity of quadrivalent influenza vaccines among healthcare personnel (HCP) aged 18–64 years over 2 consecutive seasons, HCP who received recombinant-HA influenza vaccine (RIV) or cell culture–based inactivated influenza vaccine (ccIIV) during the first season (year 1) were re-randomized the second season of 2019–2020 (year 2 [Y2]) to receive ccIIV or RIV, resulting in 4 ccIIV/RIV combinations.
In Y2, hemagglutination inhibition antibody titers against reference cell–grown vaccine viruses were compared in each ccIIV/RIV group with titers among HCP randomized both seasons to receive egg-based, standard-dose inactivated influenza vaccine (IIV) using geometric mean titer (GMT) ratios of Y2 post-vaccination titers.
RESULTS: Y2 data from 414 HCP were analyzed per protocol.
Compared with 60 IIV/IIV recipients, 74 RIV/RIV and 106 ccIIV/RIV recipients showed significantly elevated GMT ratios (Bonferroni corrected P < .007) against all components except A(H3N2).
Post-vaccination GMT ratios for ccIIV/ccIIV and RIV/ccIIV were not significantly elevated compared with IIV/IIV except for RIV/ccIIV against A(H1N1)pdm09.
CONCLUSIONS: In adult HCP, receipt of RIV in 2 consecutive seasons or the second season was more immunogenic than consecutive egg-based IIV for 3 of the 4 components of quadrivalent vaccine.
Immunogenicity of ccIIV/ccIIV was similar to that of IIV/IIV.
Differences in HA antigen content may play a role in immunogenicity of influenza vaccination in consecutive seasons.
CLINICAL TRIALS REGISTRATION: NCT03722589.
Gaglani, Manjusha,Kim, Sara S,Naleway, Allison L,Levine, Min Z,Edwards, Laura,Murthy, Kempapura,Dunnigan, Kayan,Zunie, Tnelda,Groom, Holly,Ball, Sarah,Jeddy, Zuha,Hunt, Danielle,Wesley, Meredith G,Sambhara, Suryaprakash,Gangappa, Shivaprakash,Grant, Lauren,Cao, Weiping,Gross, F Liaini,Mishina, Margarita,Fry, Alicia M,Thompson, Mark G,Dawood, Fatimah S,Flannery, Brendan, 2022, Effect of Repeat Vaccination on Immunogenicity of Quadrivalent Cell-Culture and Recombinant Influenza Vaccines Among Healthcare Personnel Aged 18–64 Years: A Randomized, Open-Label Trial, Oxford University Press
Utility of Photon-Counting Detector CT Myelography for the Detection of CSF-Venous Fistulas
imaging photon-counting myelography
