Projection-Specific Heterogeneity of the Axon Initial Segment of Pyramidal Neurons in the Prelimbic Cortex

Hu, Ankang; Zhao, Rui; Ren, Baihui; Li, Yang; Lu, Jiangteng; Tai, Yilin

Projection-Specific Heterogeneity of the Axon Initial Segment of Pyramidal Neurons in the Prelimbic Cortex

detalle del documento

IDENTIFICACIÓN

oai:pubmedcentral.nih.gov:1031...

Tema

Original Article

Autor

Hu, Ankang Zhao, Rui Ren, Baihui Li, Yang Lu, Jiangteng Tai, Yilin

Langue

Editor

Springer Nature Singapore

Categoría

Neuroscience Bulletin

Año

2023

fecha de cotización

3/7/2024

Palabras clave

heterogeneity projection-specific

Métrico

Resumen

The axon initial segment (AIS) is a highly specialized axonal compartment where the action potential is initiated.

The heterogeneity of AISs has been suggested to occur between interneurons and pyramidal neurons (PyNs), which likely contributes to their unique spiking properties.

However, whether the various characteristics of AISs can be linked to specific PyN subtypes remains unknown.

Here, we report that in the prelimbic cortex (PL) of the mouse, two types of PyNs with axon projections either to the contralateral PL or to the ipsilateral basal lateral amygdala, possess distinct AIS properties reflected by morphology, ion channel expression, action potential initiation, and axo-axonic synaptic inputs from chandelier cells.

Furthermore, projection-specific AIS diversity is more prominent in the superficial layer than in the deep layer.

Thus, our study reveals the cortical layer- and axon projection-specific heterogeneity of PyN AISs, which may endow the spiking of various PyN types with exquisite modulation.

SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12264-023-01038-5.

Hu, Ankang,Zhao, Rui,Ren, Baihui,Li, Yang,Lu, Jiangteng,Tai, Yilin, 2023, Projection-Specific Heterogeneity of the Axon Initial Segment of Pyramidal Neurons in the Prelimbic Cortex, Springer Nature Singapore