detalle del documento
IDENTIFICACIÓN
oai:pubmedcentral.nih.gov:1038...
Tema
Original ArticleAutor
Chen, Yeru Zheng, Du Wang, Hongwei Zhang, Shuxia Zhou, Youfa Ke, Xinlong Chen, GangLangue
enEditor
Springer Nature Singapore
Categoría
Neuroscience Bulletin
Año
2023
fecha de cotización
7/8/2024
Palabras clave
induced lcn2Resumen
The incidence rate of anxiety and depression is significantly higher in patients with inflammatory bowel diseases (IBD) than in the general population.
The mechanisms underlying dextran sulfate sodium (DSS)-induced depressive-like behaviors are still unclear.
We clarified that IBD mice induced by repeated administration of DSS presented depressive-like behaviors.
The paraventricular thalamic nucleus (PVT) was regarded as the activated brain region by the number of c-fos-labeled neurons.
RNA-sequencing analysis showed that lipocalin 2 (Lcn2) was upregulated in the PVT of mice with DSS-induced depressive behaviors.
Upregulating Lcn2 from neuronal activity induced dendritic spine loss and the secreted protein induced chemokine expression and subsequently contributed to microglial activation leading to blood-brain barrier permeability.
Moreover, Lcn2 silencing in the PVT alleviated the DSS-induced depressive-like behaviors.
The present study demonstrated that elevated Lcn2 in the PVT is a critical factor for DSS-induced depressive behaviors.
SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12264-023-01047-4.
Chen, Yeru,Zheng, Du,Wang, Hongwei,Zhang, Shuxia,Zhou, Youfa,Ke, Xinlong,Chen, Gang, 2023, Lipocalin 2 in the Paraventricular Thalamic Nucleus Contributes to DSS-Induced Depressive-Like Behaviors, Springer Nature Singapore
Utility of Photon-Counting Detector CT Myelography for the Detection of CSF-Venous Fistulas
imaging photon-counting myelography
