detalle del documento
IDENTIFICACIÓN
oai:pubmedcentral.nih.gov:1060...
Tema
Original ArticleAutor
Song, Siyuan Yuan, Yumin Xu, Lingling Jiang, Jun Li, Ying Yan, Yao Li, Qing Zhou, Fang Cao, Junli Zhang, LicaiLangue
enEditor
Springer Nature Singapore
Categoría
Neuroscience Bulletin
Año
2023
fecha de cotización
1/11/2023
Palabras clave
associated nucleusResumen
We previously identified a unique nucleus, the cerebrospinal fluid (CSF)-contacting nucleus.
This study aims to understand its gene architecture and preliminarily suggest its functions.
The results showed that there were about 19,666 genes in this nucleus, of which 913 were distinct from the dorsal raphe nucleus (non-CSF contacting).
The top 40 highly-expressed genes are mainly related to energy metabolism, protein synthesis, transport, secretion, and hydrolysis.
The main neurotransmitter is 5-HT.
The receptors of 5-HT and GABA are abundant.
The channels for Cl(–), Na(+), K(+), and Ca(2+) are routinely expressed.
The signaling molecules associated with the CaMK, JAK, and MAPK pathways were identified accurately.
In particular, the channels of transient receptor potential associated with nociceptors and the solute carrier superfamily members associated with cell membrane transport were significantly expressed.
The relationship between the main genes of the nucleus and life activities is preliminarily verified.
Song, Siyuan,Yuan, Yumin,Xu, Lingling,Jiang, Jun,Li, Ying,Yan, Yao,Li, Qing,Zhou, Fang,Cao, Junli,Zhang, Licai, 2023, Genetic Architecture and Functional Implications of the CSF-Contacting Nucleus, Springer Nature Singapore
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