detalle del documento
IDENTIFICACIÓN
oai:arXiv.org:2010.02182
Tema
Condensed Matter - Soft Condensed ... Quantitative Biology - Subcellular...Autor
Ziebert, Falko Kulić, Igor M.Categoría
ciencias: biología cuantitativa
Año
2020
fecha de cotización
30/6/2021
Palabras clave
influenzaResumen
While often believed to be a passive agent that merely exploits its host's metabolism, influenza virus has recently been shown to actively move across glycan-coated surfaces.
This form of enzymatically driven surface motility is currently not well understood and has been loosely linked to burnt-bridge Brownian ratchet mechanisms.
Starting from known properties of influenza's spike proteins, we develop a physical model that quantitatively describes the observed motility.
It predicts a collectively emerging dynamics of spike proteins and surface bound ligands that combined with the virus' geometry give rise to a self-organized rolling propulsion.
We show that in contrast to a Brownian ratchet, the rotary spike drive is not fluctuation driven but operates optimally as a macroscopic engine in the deterministic regime.
The mechanism also applies to relatives of influenza and to man-made analogues like DNA-monowheels and should give guidelines for their optimization.
;Comment: 5 pages , 4figures
Ziebert, Falko,Kulić, Igor M., 2020, How Influenza's Spike Motor Works
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