The multi-level regulation of clownfish metamorphosis by thyroid hormones

Roux, Natacha; Miura, Saori; Dussene, Mélanie; Tara, Yuki; Lee, Fiona; de Bernard, Simon; Reynaud, Mathieu; Salis, Pauline; Barua, Agneesh; Boulahtouf, Abdelhay; Balaguer, Patrick; Gauthier, Karine; Lecchini, David; Gibert, Yann; Besseau, Laurence; Laudet, Vincent

The multi-level regulation of clownfish metamorphosis by thyroid hormones

detalle del documento

IDENTIFICACIÓN

oai:HAL:hal-03977652v1

Tema

Coral reef Clownfish Metamorphosis Thyroid hormones Transcriptomic Vision Metabolism [SDV]Life Sciences [q-bio]

Autor

Roux, Natacha Miura, Saori Dussene, Mélanie Tara, Yuki Lee, Fiona de Bernard, Simon Reynaud, Mathieu Salis, Pauline Barua, Agneesh Boulahtouf, Abdelhay Balaguer, Patrick Gauthier, Karine Lecchini, David Gibert, Yann Besseau, Laurence Laudet, Vincent

Langue

Editor

HAL CCSD;Elsevier Inc

Categoría

ciencias: ciencias de la vida

Año

2023

fecha de cotización

15/12/2023

Palabras clave

thyroid hormones

Métrico

Resumen

International audience; Most marine organisms have a biphasic life cycle during which a pelagic larva is transformed into a radically different juvenile.

In vertebrates the role of thyroid hormones (TH) in triggering this transition is well known, but how the morphological and physiological changes are integrated in a coherent way with the ecological transition remains poorly explored.

To gain insight into this question, we performed an integrative analysis of metamorphosis of a marine teleost, the clownfish Amphiprion ocellaris.

We reveal how TH coordinate a change in color vision as well as a major metabolic shift in energy production, hence highlighting its central integrative role in regulating this transformation.

By manipulating the activity of LXR, a major regulator of metabolism, we also reveal a tight link between metabolic changes and metamorphosis progression.

Strikingly, we observed that these regulations are at play in the wild revealing how hormones coordinate energy needs with available resources during life cycle.

Roux, Natacha,Miura, Saori,Dussene, Mélanie,Tara, Yuki,Lee, Fiona,de Bernard, Simon,Reynaud, Mathieu,Salis, Pauline,Barua, Agneesh,Boulahtouf, Abdelhay,Balaguer, Patrick,Gauthier, Karine,Lecchini, David,Gibert, Yann,Besseau, Laurence,Laudet, Vincent, 2023, The multi-level regulation of clownfish metamorphosis by thyroid hormones, HAL CCSD;Elsevier Inc