detalle del documento
IDENTIFICACIÓN
oai:HAL:hal-04281691v1
Tema
HIV Non-AIDS defining cancer AIDS defining cancer Incidence Trends Smoking Infection Body mass index [SDV.SPEE]Life Sciences [q-bio]/Sa...Autor
Greenberg, Lauren Ryom, Lene Bakowska, Elzbieta Wit, Ferdinand Bucher, Heiner C. Braun, Dominique L. Phillips, Andrew Sabin, Caroline d'Arminio Monforte, Antonella Zangerle, Robert Smith, Colette de Wit, Stephane Bonnet, Fabrice Pradier, Christian Mussini, Cristina Muccini, Camilla Vehreschild, Jorg J Hoy, Jennifer Svedhem, Veronica Miro, Jose M. Wasmuth, Jan-Christian Reiss, Peter Llibre, Josep M Chkhartishvili, Nikoloz Stephan, Christoph Hatleberg, Camilla I. Neesgaard, Bastian Peters, Lars Jaschinski, Nadine Dedes, Nikos Kuzovatova, Elena van der Valk, Marc Menozzi, Marianna Lehmann, Clara Petoumenos, Kathy Garges, Harmony Rooney, Jim Young, Lital Lundgren, Jens D. Bansi-Matharu, Loveleen Mocroft, AmandaLangue
enEditor
HAL CCSD;MDPI
Categoría
ciencias: ciencias de la vida
Año
2023
fecha de cotización
15/12/2023
Palabras clave
pyfu amongst hiv [2 bmi-related cancer trends cancers incidenceResumen
International audience; Despite cancer being a leading comorbidity amongst individuals with HIV, there are limited data assessing cancer trends across different antiretroviral therapy (ART)-eras.
We calculated age-standardised cancer incidence rates (IRs) from 2006-2021 in two international cohort collaborations (D:A:D and RESPOND).
Poisson regression was used to assess temporal trends, adjusted for potential confounders.
Amongst 64,937 individuals (31% ART-naïve at baseline) and 490,376 total person-years of follow-up (PYFU), there were 3763 incident cancers (IR 7.7/1000 PYFU [95% CI 7.4, 7.9]): 950 AIDS-defining cancers (ADCs), 2813 non-ADCs, 1677 infection-related cancers, 1372 smoking-related cancers, and 719 BMI-related cancers (groups were not mutually exclusive).
Age-standardised IRs for overall cancer remained fairly constant over time (8.22/1000 PYFU [7.52, 8.97] in 2006-2007, 7.54 [6.59, 8.59] in 2020-2021).
The incidence of ADCs (3.23 [2.79, 3.72], 0.99 [0.67, 1.42]) and infection-related cancers (4.83 [4.2, 5.41], 2.43 [1.90, 3.05]) decreased over time, whilst the incidence of non-ADCs (4.99 [4.44, 5.58], 6.55 [5.67, 7.53]), smoking-related cancers (2.38 [2.01, 2.79], 3.25 [2.63-3.96]), and BMI-related cancers (1.07 [0.83, 1.37], 1.88 [1.42, 2.44]) increased.
Trends were similar after adjusting for demographics, comorbidities, HIV-related factors, and ART use.
These results highlight the need for better prevention strategies to reduce the incidence of NADCs, smoking-, and BMI-related cancers.
Greenberg, Lauren,Ryom, Lene,Bakowska, Elzbieta,Wit, Ferdinand,Bucher, Heiner C.,Braun, Dominique L.,Phillips, Andrew,Sabin, Caroline,d'Arminio Monforte, Antonella,Zangerle, Robert,Smith, Colette,de Wit, Stephane,Bonnet, Fabrice,Pradier, Christian,Mussini, Cristina,Muccini, Camilla,Vehreschild, Jorg J,Hoy, Jennifer,Svedhem, Veronica,Miro, Jose M.,Wasmuth, Jan-Christian,Reiss, Peter,Llibre, Josep M,Chkhartishvili, Nikoloz,Stephan, Christoph,Hatleberg, Camilla I.,Neesgaard, Bastian,Peters, Lars,Jaschinski, Nadine,Dedes, Nikos,Kuzovatova, Elena,van der Valk, Marc,Menozzi, Marianna,Lehmann, Clara,Petoumenos, Kathy,Garges, Harmony,Rooney, Jim,Young, Lital,Lundgren, Jens D.,Bansi-Matharu, Loveleen,Mocroft, Amanda, 2023, Trends in Cancer Incidence in Different Antiretroviral Treatment-Eras amongst People with HIV, HAL CCSD;MDPI
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